http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2871524-T3
Outgoing Links
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| filingDate | 2014-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_398bb2bb373cde5221bf176c516bfe28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2743611e658fefceb751e3e570a3834f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_867fc4cc0e23d3036cbb20ddb76e889a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86644adef04877f470858eb0dd4e836f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e279ecce4764220d6ba2f9137ca48d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6bd6ff8fb24b3e690857e731bb25eb5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2435511e79a50c7b82cffc3904c86bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d336e494cd2746003c14e51255ab105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62285725e60008c5f0a97ca1b34b7d6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a25233d5c25e236d058d19b7eedc56ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4257e5afd80c7840b721a90f4ec9c2df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dff6bffe49d77691a1b6c9e1570f1850 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62b49a30ce802049fa93b1b64520684f |
| publicationDate | 2021-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2871524-T3 |
| titleOfInvention | Pyrrolo [2,3-d] pyrimidinyl, pyrrolo [2,3-b] pyrazinyl, and pyrrolo [2,3-d] pyridinyl acrylamides |
| abstract | A compound having the structure: **(See Formula)** or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer or diastereomer thereof, and wherein R2 is selected from the group consisting of hydrogen, deuterium, C1-C6 straight or branched chain alkyl, C3-C6 cycloalkyl, C6-C10 aryl, monocyclic or bicyclic heteroaryl, comprising 5 and/or 6 membered rings, C1-C6 straight or branched chain alkyl (aryl), ( heteroaryl) C1-C6 straight or branched chain alkyl, (heterocyclic) C1-C6 straight or branched chain alkyl, (C1-C6 straight or branched chain alkyl)aryl, (C1-C6 straight or branched chain alkyl)heteroaryl , (C1-C6 straight or branched chain alkyl)heterocyclic, C1-C6 straight or branched chain perfluoroalkyl, C1-C6 straight or branched chain alkoxy, C1-C6 straight or branched perfluoroalkoxy, halogen, cyano, hydroxyl, amino, carboxy, aminocarbonyl, (C1-C6 straight or branched chain alkyl) aminocarbonylamino, (C1-C6 straight or branched chain alkyl)aminocarbonyl, -SOR12, -SO2R12, -NR13SO2R12, -SO2NR13R14, and -NR13SO2NR14R15; wherein said alkyl, aryl and heteroaryl is independently optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, cyano, alkylamino, dialkylamino, CF3, aminocarbonyl, (C1-C6 chain alkyl linear or branched) aminocarbonyl and C3-C6 cycloalkyl; R3 is selected from the group consisting of hydrogen, deuterium, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain perfluoroalkyl, halogen, and cyano; A is -(CRaRb)q-(CRcRd)r-, wherein Ra, Rb, Rc and Rd are independently selected from hydrogen, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain perfluoroalkyl, C6-C10 aryl, monocyclic or bicyclic heteroaryl, comprising 5 and/or 6 membered rings, alkylaryl, (aryl) C1-C6 straight or branched chain alkyl, (heteroaryl) C1-C6 straight or branched chain alkyl, halogen , cyano, hydroxyl, C1-C6 straight or branched chain alkoxy, amino, carboxy, aminocarbonyl, (heterocyclic) C1-C6 straight or branched chain alkyl, (C1-C6 straight or branched chain alkyl)aryl, (C1 alkyl -C6 straight or branched chain)heteroaryl and (C1-C6 straight or branched chain alkyl)heterocyclic, wherein said alkyl is optionally further substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, alkylamino, dialkylamino, CF3 and C3-C6 cycloalkyl; R0, R1, R4, R5, R6, R7, R8, R9 and R10 are independently selected from hydrogen, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain perfluoroalkyl, C6-C10 aryl, monocyclic heteroaryl or bicyclic, comprising 5 and/or 6 membered rings, (aryl) C1-C6 straight or branched chain alkyl, (heteroaryl) C1-C6 straight or branched chain alkyl, heteroaryl, halogen, cyano, hydroxyl, C1 alkoxy -C6 straight or branched chain, amino, carboxy, aminocarbonyl, (heterocyclic) C1-C6 straight or branched chain alkyl, (C1-C6 straight or branched chain alkyl)aryl, (C1-C6 straight or branched chain alkyl )heteroaryl and heterocyclic (C1-C6 straight or branched chain alkyl), wherein said alkyl is optionally further substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, alkylamino, dialkylamino, CF3 and C3-C6 cycloalkyl; wherein, alternatively, R0 or R1 and/or R6 or R7, respectively together with R4, R5, Ra, Rb, Rc or Rd, may independently form a bond or a linear C1-C6 alkyl chain; and/or, alternatively, R4 or R5, respectively together with Ra, Rb, Rc or Rd, may independently form a bond or a linear C1-C6 alkyl chain; and/or, alternatively, R8 and R9 may together form a 3-6 membered ring optionally containing one or two O or N atoms; R11 is hydrogen or deuterium; R12, R13, R14 and R15 are independently selected from hydrogen, C1-C6 straight or branched chain alkyl, C1-C6 straight or branched chain perfluoroalkyl, C6-C10 aryl, alkylaryl, and C1 straight or branched chain alkyl (aryl). -C6; Y is 0 or N, wherein when Y is 0, n is 0; one and only one of the discontinuous bonds to Z and Z' constitutes a single bond, the other being absent, and also Z is C when the discontinuous bond to Z is a single bond and Z' is N or CR16; or, Z is CR16 or N when the discontinuous bond to Z' is a single bond and Z' is C; wherein R16 is C1-C4 alkyl, C6-C10 aryl, monocyclic or bicyclic heteroaryl, comprising 5 and/or 6 membered rings, (aryl)C1-C6 straight or branched chain alkyl, (heteroaryl)C1-alkyl C6 straight or branched chain, (heterocyclic) C1-C6 straight or branched chain alkyl, (C1-C6 straight or branched chain alkyl)aryl, (C1-C6 straight or branched chain alkyl)heteroaryl, or (C1-C6 alkyl) C6 straight or branched chain)heterocyclic, wherein said alkyl is optionally further substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, CF3, and C3-C6 cycloalkyl; X and discontinuous bonds thereof may be present or absent, whereby, (a) if X is present, Y is N and X is O or -(CReRf)s-, where Re and Rf are independently hydrogen , deuterium, halo, hydroxy, C1-C4 alkoxy, amino, CF3, C1-C6 straight or branched chain alkyl, C3-C6 cycloalkyl, C6-C10 aryl, monocyclic or bicyclic heteroaryl, comprising rings of 5 and/or 6 members, (aryl) C1-C6 straight or branched chain alkyl, (C1-C6 straight or branched chain alkyl)heteroaryl, (heteroaryl) C1-C6 straight or branched chain alkyl or (heterocyclic) C1-C6 straight chain alkyl linear or branched and said discontinuous bonds are present and are single bonds, whereby, when n is 0 and X is O, said O is bonded to H and said discontinuous bond between X and -(CH2)n- is absent, and when X is -(CReRf)s-, and X is directly linked to Y; and (b) if X is absent, said discontinuous bonds are absent and n is 0, whereby, when Y is N, (i) said N atom is substituted with H, (ii) Z is C, Z' is C or N, the discontinuous bond to Z is a single bond, the discontinuous bond to Z' being absent or (iii) Z is C or N, Z' is C, the discontinuous bond to Z' is a single bond, the discontinuous bond being absent discontinuous bond to Z, wherein said Y which is an N atom may, together with R2 and intervening atoms therebetween, form a 6-membered ring optionally substituted with C1-C6 straight or branched chain alkyl or cycloalkyl C3-C6; n, p, q, r and s are independently 0, 1 or 2; in a pharmaceutically acceptable form in combination with one or more additional agents that modulate a mammalian immune system or that are anti-inflammatory. |
| priorityDate | 2013-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1230.