abstract |
A modified IgG4 Fc fragment, comprising a modified hinge region, in which the hinge region of sequence Glu-Ser-Lys-Tyr-Gly-Pro-Pro-Cys-Pro-Ser-Cys-Pro was modified by deleting part of its amino acid sequence to include only one cysteine residue, so that the hinge consists of Pro-Ser-Cys-Pro. |