http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2867552-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9008466a40998f8be8e54cd3aceb10a2 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 |
filingDate | 2014-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_993ecd84009a982adc1e94cd010f7bf9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a533fc49639fab21d83e5f995de7aeca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3903bf5e75f5ad632c0d78e5b33246a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d717650decf4bd29c3505ee8dd7be7c0 |
publicationDate | 2021-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2867552-T3 |
titleOfInvention | Dry powder formulation comprising an anticholinergic, a corticosteroid and a beta adrenergic for administration by inhalation |
abstract | A dry powder formulation for use in a dry powder inhaler (DPI) to be administered by inhalation, said formulation comprising: a) a fine particle fraction consisting of a mixture of 90 to 99.5 weight percent of particles micronized of a physiologically acceptable excipient and 0.5 to 10 percent by weight of magnesium stearate, in which at least 90% of all said particles have a volume diameter less than 15 microns, and the average diameter of the volume of the mentioned particles is between 3 and 7 microns, and no more than 10% of the mentioned particles have a diameter less than 1.8 microns; b) a fraction of coarse particles consisting of a physiologically acceptable excipient having a mean mass diameter equal to or greater than 100 microns, in which the ratio between the fine particles mentioned a) and the coarse particles b) is from 1 : 99 and 30:70 percent by weight; c) micronized particles of glycopyrronium bromide, beclomethasone dipropionate and formoterol fumarate dihydrate as active ingredients; wherein at least 90% of the micronized particles of each active ingredient have a volume diameter equal to or less than 6 microns, and the formulation delivers a therapeutically effective dose of the three active ingredients comprised between 100 and 500 microg; wherein said formulation can be obtained by a process comprising the steps of i) co-mixing in a high energy apparatus for a period of less than 30 minutes the excipient and magnesium stearate particles; and ii) mixing the fine particle fraction a), the lactose coarse particle fraction b) and all micronized active ingredients; and therefore, after administration from the inhaler, the formulation delivers a fraction of active particles equal to or greater than 30% having a particle size equal to or less than 2.0 microns. |
priorityDate | 2013-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.