| abstract |
An immunogenic composition comprising an immunologically effective amount of at least one antigenic polysaccharide, an immunologically effective amount of at least one peptide or polypeptide antigen, and at least one pair of affinity molecules, wherein the or each pair comprises a first affinity molecule and a second affinity molecule complementary to the first affinity molecule, wherein, in or in each pair: the first affinity molecule is associated with one of the at least one antigenic polysaccharide, and the second complementary affinity molecule is associated with one of the at least one peptide or polypeptide antigen, and the or each first affinity molecule is non-covalently associated with the or each second complementary affinity molecule to bind the peptide or polypeptide antigen (s) and the antigenic polysaccharide (s); and wherein the immunogenic composition can elicit (i) an immune response to the at least one antigenic polysaccharide, and (ii) an immune response to the at least one peptide or polypeptide antigen, in a subject after administration of the composition to the subject. |