http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2864707-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87729a8c288798b59d4c537ff5edd381 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2014-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33e1c6308b06aa1453c2d6d3c77b3879 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3203b63e1964192d2170ec2bda38f93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_415edac47585e52b1c49c5c66175edba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8347cb5a6be48b371fa9e9227f8a95ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e2e497f22995fae4261d96f1e932e59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a55c681af44bd13d4b463dc4234bb460 |
| publicationDate | 2021-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2864707-T3 |
| titleOfInvention | Compounds and their uses for modulation of hemoglobin |
| abstract | A compound of Formula (IIA): ** (See formula) ** or a tautomer thereof, or a pharmaceutically acceptable salt of each, wherein Ring A is an optionally substituted 4 to 10 membered cycloalkyl or heterocycle 4- to 10-membered containing up to 5 ring heteroatoms, wherein the heteroatom is selected from the group consisting of O, N, S, and oxidized forms of N and S; Ring B is a 5-10 membered C6-C10 aryl or heteroaryl having 1-3 nitrogen atoms, or oxidized versions thereof, wherein the aryl or heteroaryl is optionally substituted; it is a single or double bond; R5 is hydrogen or C1-C6 alkyl, wherein the C1-C6 alkyl is optionally substituted with 1-5 halo; R6 is halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkyl-S (O) - or C1-C6 alkyl S (O) 2-, wherein the C1-C6 alkyl is optionally substituted with 1-5 halo; or R6 is cycloalkyl or 4-10 membered heterocycle substituted with an R'R'N moiety wherein each R 'is independently C1-C6 alkyl or hydrogen; p is 0, 1, 2 or 3; wherein the term "heterocyclyl" or "heterocycle" refers to a non-aromatic, mono, bi, or tricyclic ring containing 2-12 ring carbon atoms and 1-8 ring heteroatoms; preferably wherein, unless otherwise indicated, "optionally substituted" refers to a substituted or unsubstituted group, wherein the group may be substituted with one or more substituents selected from the group consisting of oxo, halo, -CN , NO2, -N2 +, -CO2R100, -OR100, -SR100, -SOR100, -SO2R100, -NR101R102, -CONR101R102, -SO2NR101R102, C1-C6 alkyl, C1-C6 alkoxy, -CR100 = C (R100) 2, - CCR100, C3-C10 cycloalkyl, C3-C10 heterocyclyl, C6-C12 aryl and C2-C12 heteroaryl, where each R100 is independently hydrogen, C1-C8 alkyl, C3-C12 cycloalkyl, C3-C10 cycloalkyl heterocyclyl, C6-C12 aryl , or C2-C12 heteroaryl; wherein each alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with 1-3 halo, 1-3 C1-C6 alkyl, 1-3 C1-C6 haloalkyl or 1-3 C1-C6 alkoxy; and R101 and R102 are independently hydrogen, C1-C8 alkyl, optionally substituted with -CO2H or an ester thereof, C1-C6 alkoxy, oxo, -CR103 = C (R103) 2, -CCR, C3-C10 cycloalkyl, C3- C10 heterocyclyl, C6-C12 aryl or C2-C12 heteroaryl, wherein each R103 is independently hydrogen, C1-C8 alkyl, C3-C12 cycloalkyl, C3-C10 heterocyclyl, C6-C12 aryl or C2-C12 heteroaryl; wherein each cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with 1-3 alkyl groups or 1-3 halo groups, or R101 and R102 together with the nitrogen atom are linked to form a 5-7 membered heterocycle. |
| priorityDate | 2013-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.