http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2864079-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-451 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 |
filingDate | 2015-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67552b7b38aea238f899d93ce62fa988 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db8ec2f05df264be7480f8698e01df82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a25233d5c25e236d058d19b7eedc56ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c576bd4ce7958b1d772881f247ca1a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_398bb2bb373cde5221bf176c516bfe28 |
publicationDate | 2021-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2864079-T3 |
titleOfInvention | Carbonitrile derivatives as selective androgen receptor modulators |
abstract | A compound of Formula 1, Formula 2 or Formula 3, ** (See formula) ** in which A is N or -CR0-, in which R0 is hydrogen, C1-C6 straight or branched chain alkyl, perfluoroalkyl, straight or branched chain C1-C6 aryl, perfluoroaryl, alkylaryl, heteroaryl; or alkylheteroaryl; X and Y are independently -CH2-, -CHRa- or, -CRaRb-, where Ra and Rb are independently straight or branched chain C1-C6 alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; or, Ra and Rb together form a chain comprising - (CH2) j--, - (CHRc) j--, or - (CRcRd) j--, where Rc and Rd are independently C1-C6 alkyl chain straight or branched C1-C6 straight or branched chain alkyl, perfluoroalkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where j is 2; 3, 4 or 5; Z is -CRe-, or -N-, where Re is hydrogen, straight or branched chain C1-C6 alkyl, perfluoroalkyl, aryl, alkylaryl, heteroaryl or straight or branched chain C1-C6 alkylheteroaryl; R1 is hydrogen, straight or branched chain C1-C6 alkyl, aryl, perfluoroalkyl, alkylaryl, heteroaryl, alkylheteroaryl, straight or branched chain C1-C6 alkoxycarbonyl, straight or branched chain C1-C6 alkylaminocarbonylamino, straight or branched chain alkyloxycarbonylamino C1-C6, C1-C6 straight or branched chain alkylcarbonylamino or C1-C6 straight or branched chain alkylaminocarbonyl; R2 is independently hydrogen or straight or branched chain C1-C6 alkyl; R3 and R4 are independently hydrogen, straight or branched chain C1-C6 alkyl, straight or branched chain C1-C6 perfluoroalkyl, straight or branched chain C1-C6 perfluoroalkoxy, halogen, cyano, hydroxyl, amino, carboxyl, aryl, heteroaryl straight or branched chain, C1-C6 alkoxycarbonyl, straight or branched chain C1-C6 alkylaminocarbonylamino or straight or branched chain C1-C6 alkylaminocarbonyl; R5 and R6 are independently hydrogen or straight or branched chain C1-C6 alkyl, straight or branched chain C1-C6 perfluoroalkyl, cyano, hydroxyl, amino, carboxyl, aryl, heteroaryl or, R5 and R6 together form a chain comprising - (CH2) k-, - (CHR7) k--, or - (CR7aR7b) k-, where R7, R7a and R7b are independently straight or branched chain C1-C6 alkyl, perfluoroalkyl, aryl, alkylaryl, heteroaryl or straight or branched chain C1-C6 alkylheteroaryl; where k is 2; 3, 4 or 5; R8 is hydrogen, straight or branched chain C1-C6 alkyl, perfluoroalkyl, aryl, aryl substituted with one, two or three fluorine atoms, perfluoroaryl, alkylaryl, straight or branched chain C1-C6 heteroaryl; or alkylheteroaryl; or, R1 and R8 together form a chain comprising - (CH2) m--, - (CHRf) m--, or - (CRfRg) m--, where Rf and Rg are independently alkyl, aryl, alkylaryl straight or branched chain, heteroaryl or C1-C6 alkylheteroaryl; where m is 2; 3, 4 or 5; R9 and R10 are independently hydrogen or straight or branched chain C1-C6 alkyl, straight or branched chain C1-C6 perfluoroalkyl, cyano, hydroxyl, amino, carboxyl, aryl, heteroaryl or, R9 and R10 together form a chain comprising - - (CH2) p-, - (CHRh) p-, or - (CRhRi) p-, wherein Rh and Ri are independently straight or branched chain C1-C6 alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where p is 2; 3, 4 or 5; Q is --CO--, - (CH2) q--, - - (CHRs) q--, or - (CRsRt) q--, where Rs and Rt are independently alkyl, aryl, alkylaryl, heteroaryl, or straight or branched chain C1-C6 alkylheteroaryl; where q is 0, 1, 2, or 3; y, where n is 0, 1, 2, 3, 4, or 5; or a pharmaceutically acceptable salt thereof; for use in treating and / or preventing a disorder or condition in a subject, wherein the disorder or condition is selected from the group consisting of benign prostatic hyperplasia; Cancer; atherosclerosis and its associated diseases; dysmenorrhea; dyspermatogenic sterility; respiratory tract disease; otorhinolaryngological disease; androgen deprivation therapy; central nervous system injuries; an infection; digestive system disease; urological or male genital disease; dermatological disorder; endocrine disorder; lymphatic disorder; congenital / hereditary or neonatal disease; connective tissue disease; environmental disorder; a mental disorder; a cognitive disorder; liver disease; kidney disease and diabetic nephropathy. |
priorityDate | 2014-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 2465.