| abstract |
A compound having a formula or salt thereof, wherein: R2 is H, substituted or unsubstituted aliphatic, substituted or unsubstituted heteroaliphatic, substituted or unsubstituted heterocycloaliphatic, substituted or unsubstituted aryl, amide, substituted or unsubstituted heterocyclyl , or substituted or unsubstituted araliphatic; each R3 is independently H, substituted or unsubstituted aliphatic, halogen, substituted or unsubstituted heteroaliphatic, -O-substituted or unsubstituted aliphatic, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted araliphatic, -O- substituted or unsubstituted heterocyclyl, hydroxyl, nitro, cyano, carboxyl, carboxylic ester, acyl, amide, amino, sulfonyl, sulfonamide, sulfanyl, sulfinyl, haloalkyl, alkylphosphate, or alkylphosphonate, wherein R3 is not pyridinyl; x is 1 to 6; y is 1 to 6; z is 1 to 6; Het-1 is furyl, thiazolyl, or oxazolyl; Het-2 is 5- or 6-membered heteroaryl; and Het-3 is pyrazolyl wherein a substituent for substituting one or more hydrogen atoms on a saturated carbon atom in the specified group or moiety is -R60, halo, = O, -OR70, -SR70, -N (R80 ) 2, haloalkyl, perhaloalkyl, -CN, -NO2, = N2, -N3, -SO2R70, -SO3-M +, -SO3R70, -OSO2R70, -OSO3-M +, -OSO3R70, -P (O) (O-) 2 (M +) 2, -P (O) (O-) 2M2 +, -P (O) (OR70) O-M +, -P (O) (OR70) 2, - C (O) R70, -C (S ) R70, -C (NR70) R70, -CO2-M +, -CO2R70, -C (S) OR70, -C (O) N (R80) 2, -C (NR70) (R80) 2, -OC (O ) R70, -OC (S) R70, -OCO2-M +, -OCO2R70, -OC (S) OR70, -NR70C (O) R70, -NR70C (S) R70, -NR70CO2-M +, -NR70CO2R70, -NR70C ( S) OR70, - NR70C (O) N (R80) 2, -NR70C (NR70) R70 and -NR70C (NR70) N (R80) 2, where R60 is C1-6 alkyl optionally substituted with 1, 2 or 3 OH; each R70 is, independently for each occurrence, hydrogen or R60; each R80 is, independently for each occurrence, R70, or alternatively, two R80 groups, taken together with the nitrogen atom to which they are attached, form a 3 to 7 membered heteroalicyclyl optionally including 1 to 4 of the same additional heteroatoms or different ones selected from O, N and S, of which N optionally has a substitution of H or C1-C3 alkyl; and each M + is a counterion with a single net positive charge; a substituent to replace a hydrogen atom on an unsaturated carbon atom in a group containing unsaturated carbons is -R60, halo, -O-M +, -OR70, -SR70, -S-M +, -N (R80) 2, perhaloalkyl, -CN, -OCN, -SCN, -NO, -NO2, -N3, -SO2R70, -SO3-M +, -SO3R70, -OSO2R70, -OSO3-M +, -OSO3R70, -PO3-2 (M +) 2 , -PO3-2M2 +, -P (O) (OR70) O-M +, - P (O) (OR70) 2, -C (O) R70, -C (S) R70, -C (NR70) R70, - CO2-M +, -CO2R70, -C (S) OR70, -C (O) NR80R80, -C (NR70) N (R80) 2, - OC (O) R70, -OC (S) R70, -OCO2-M + , -OCO2R70, -OC (S) OR70, -NR70C (O) R70, -NR70C (S) R70, -NR70CO2-M +, -NR70CO2R70, -NR70C (S) OR70, -NR70C (O) N (R80) 2 , -NR70C (NR70) R70 or -NR70C (NR70) N (R80) 2, in which R60, R70, R80 and M + are as defined above, provided that in each case of substituted alkene or alkyne, the substituents are not -OM +, -OR70, -SR70, or -S-M +; and a substituent group to replace a hydrogen atom on a nitrogen atom in a group containing said nitrogen atom is -R60, -O-M +, -OR70, -SR70, -S-M +, -N (R80) 2 , perhaloalkyl, -CN, -NO, -NO2, -S (O) 2R70, - SO3-M +, -SO3R70, -OS (O) 2R70, -OSO3-M +, -OSO3R70, -PO32- (M +) 2, -PO32-M2 +, -P (O) (OR70) O-M +, -P (O) (OR70) (OR70), - C (O) R70, -C (S) R70, -C (NR70) R70, -CO2R70, -C (S) OR70, -C (O) NR80R80, -C (NR70) NR80R80, -OC (O) R70, -OC (S) R70, - OCO2R70, -OC (S) OR70, -NR70C (O) R70, -NR70C (S) R70, -NR70CO2R70, -NR70C (S) OR70, -NR70C (O) N (R80) 2, - NR70C (NR70) R70 or -NR70C (NR70) N (R80) 2 wherein R60, R70, R80 and M + are as defined above. |