| abstract |
A method of producing a matrix for restoring soft tissue, comprising: forming a sheet-like absorption layer (11) on one side of a double layer using biocompatible neutral collagen; forming a film-like support layer (12) on a remaining surface of the double layer by mixing collagen with a water-soluble polymer selected from polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, or the combination thereof; and a natural material selected from alginate and genipin; and forming a double layer structured matrix (10) to restore soft tissue by joining the absorption layer (11) and the support layer (12), to treat soft tissue damage of a mammal other than a human or restore damaged soft tissue; wherein forming said support layer (12) comprises: dissolving and mixing collagen, said water soluble polymer, and said natural material to form a mixed solution, and crosslinking said mixed solution; and wherein the amount of said collagen is 0.3 to 1.0% (w / v) and the amount of said water-soluble polymer is 0.9 to 2.5% (w / v), based on weight total of said mixed solution. |