| abstract |
A compound of Formula (II): ** (See formula) ** where: -OZ-CO2H is ** (See formula) ** -O-heteroalkyl-CO2H, -O-cyclyl-CO2H, -O-CH2 -cyclyl-CO2H, -O-cyclyl-CH2-CO2H, or -O-CH2-cyclyl-CH2-CO2H, each of which may be optionally substituted with one to six substituents independently selected from halide, cyano, nitro, hydroxyl , -SH, -NH2, -OR11, -SR11, -NR12R13, -C (= O) R11, -C (= O) OR11, -OC (= O) R11, - C (= O) NR12R13, -NR11C (= O) R11, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein: -cyclyl- is -cycloalkyl-, -heterocyclyl-, -aryl- or -heteroaryl-; R7 and R8 are each independently hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl, or R7 and R8 and the carbon atom to which they are connected form a C3-C6 cycloalkyl ring; R11 at each occurrence is independently hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R12 and R13 at each occurrence are independently hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, or R12 and R13 and the nitrogen atom to which they are connected form a heterocyclic or heteroaryl ring; and n is an integer from 1 to 10; or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof; provided that: -O-Z-CO2H is not ** (See formula) ** and -O-Z-CO2H does not contain a sugar structural unit. |