http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2858729-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2be1effe2aad8610d58162b6e1f93fb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-207 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-26 |
| filingDate | 2016-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_059d7af44010227aa14e165e35de6d64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10f26eb5bac891118df20244ff042779 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_842483dad0c307f09cace4c653aeafcc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a5becabe894eba3cf0cd2fff073e696 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8975b3f5f5cdc6744cd81c2892567516 |
| publicationDate | 2021-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2858729-T3 |
| titleOfInvention | Galectin alpha-d-galactoside inhibitors |
| abstract | A D-galactopyranose compound of formula (1) ** (See formula) ** in which the pyranose ring is α-D-galactopyranose, A is selected from ** (See formula) ** in which Het1 is selected from a five or six membered heteroaromatic ring, optionally substituted with a group selected from Br; F; Cl; CN; NR19R20, wherein R19 and R20 are independently selected from H, C1-3 alkyl, cyclopropyl, isopropyl, -C (= O) -R21, wherein R21 is selected from H and C1-3 alkyl; C1-3 alkyl, optionally substituted with an F; cyclopropyl, optionally substituted with an F; isopropyl, optionally substituted with an F; O-cyclopropyl optionally substituted with one F; O-isopropyl optionally substituted with one F; and O-C1-3 alkyl optionally substituted with one F; wherein R1-R5 are independently selected from H, CN, NH2, F, methyl optionally substituted with one F, and OCH3 optionally substituted with one F; wherein R6 is selected from C1-6 alkyl optionally substituted with halogen, branched C3-6 alkyl and C3-7 cycloalkyl; X is selected from S, SO, SO2, O, C = O, and CR7R8 wherein R7 and R8 are independently selected from hydrogen, OH, or halogen; wherein R27 is selected from C1-6 alkyl, branched C3-6 alkyl, C1-6 alkoxy, and branched C3-6 alkoxy; B is selected from a) a C1-6 alkyl or branched C3-6 alkyl substituted with a five or six membered heteroaromatic ring, optionally substituted with a substituent selected from CN, a halogen, methyl optionally substituted with an optionally substituted F, OCH3 with one F, OCH2CH3 optionally substituted with one F, OH, and R14-CONH- where R14 is selected from C1-3 alkyl and cyclopropyl; or a C1-6 alkyl substituted with a phenyl, optionally substituted with a substituent selected from CN, a halogen, methyl optionally substituted with an F, OCH3 optionally substituted with a F, OCH2CH3 optionally substituted with a F, OH and R15-CONH- wherein R15 is selected from C1-3 alkyl and cyclopropyl; b) an aryl, such as phenyl or naphthyl, optionally substituted with a group selected from a halogen; CN; -COOH; -CONR22R23, wherein R22 and R23 are independently selected from H, C1-3 alkyl, cyclopropyl, and isopropyl; C1-3 alkyl, optionally substituted with an F; cyclopropyl, optionally substituted with an F; isopropyl, optionally substituted with an F; O-C1-3 alkyl, optionally substituted with one F; O-cyclopropyl, optionally substituted with an F; O-isopropyl, optionally substituted with an F; NR28R29, wherein R28 and R29 are independently selected from H, C1-3 alkyl, and isopropyl; OH; and R16-CONH- where R16 is selected from C1-3 alkyl and cyclopropyl; c) a C5-7 cycloalkyl, optionally substituted with a substituent selected from halogen, CN, methyl optionally substituted with F, OCH3 optionally substituted with F, OCH2CH3 optionally substituted with F, OH, and R17-CONH- in the that R17 is selected from C1-3 alkyl and cyclopropyl; and d) a heterocycle, such as heteroaryl or heterocycloalkyl, optionally substituted with a group selected from halogen; CN; -COOH; -CONR24R25, wherein R24 and R25 are independently selected from H, C1-3 alkyl, cyclopropyl, and isopropyl; C1-3 alkyl, optionally substituted with an F; cyclopropyl, optionally substituted with an F; isopropyl, optionally substituted with an F; O-C1-3 alkyl, optionally substituted with one F; O-cyclopropyl, optionally substituted with an F; O-isopropyl, optionally substituted with an F; NR30R31, wherein R30 and R31 are independently selected from H, C1-3 alkyl, and isopropyl; OH; and R18-CONH- where R18 is selected from C1-3 alkyl and cyclopropyl; e) a C1-6 alkyl or branched C3-6 alkyl; or a pharmaceutically acceptable salt or solvate thereof. |
| priorityDate | 2015-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 355.