http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2858312-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 |
| filingDate | 2016-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a594c264ffe4067fb446975865f860f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2584a92d398cd910920e8a4b13662caa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd3a35652e9acc84022dbf5feff79401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32fcd428641a653b7df4163e57dc565d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e30581b7819739c7239c49bf53de8ea9 |
| publicationDate | 2021-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2858312-T3 |
| titleOfInvention | Apelin receptor agonists and methods of use |
| abstract | A compound of Formula (I): ** (See formula) ** or a stereoisomer, an enantiomer, a diastereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, wherein: alk is C1-6 alkyl substituted with 1-5 R4; ring A is independently selected from ** (See formula) ** and ring B is independently selected from ** (See formula) ** and 6-membered heteroaryl, each substituted with 1-4 R1; R1 is independently selected from H, F, Cl, Br, NO2, - (CH2) nORb, (CH2) nS (O) pRc, - (CH2) nC (= O) Rb, - (CH2) nNRa-Ra, - (CH2) nC (= O) NRaRa, - (CH2) nNRaC (= O) Rb, C1-4 alkyl substituted with 0-3 Re and C3-6 cycloalkyl substituted with 0-3 Re; R2 is independently selected from C2-5 alkyl substituted with 0-3 Re; C2-5 alkenyl, aryl substituted with 1-3 Re, heterocyclyl substituted with 0-3 Re and C3-6 cycloalkyl; provided that when R2 is C1-5 alkyl, the carbon atom and the groups attached to it, except that attached to the pyrimidine ring, may be replaced by O, N, and S; R3 is independently selected from H, halogen, - (CH2) nORb, (CH2) nS (O) pRc, - (CH2) nC (= O) Rb, - (CH2) nNRaRa, - (CH2) nCN, - (CH2 ) nC (= O) NRaRa, - (CH2) nNHC (= O) Rb, - (CH2) nNHC (= O) NRaRa, - (CH2) nNHC (= O) ORb, - (CH2) nOC (= O) NRaRa, - (CH2) nC (= O) ORb, - (CH2) nS (O) pNRaRa, - (CH2) nNHS (O) pNRaRa, - (CH2) nNHS (O) pRc, C1-5 alkyl substituted with 0 -3 Re, (CH2) n-C3-6 carbocyclyl substituted with 0-3 Re and - (CH2) n-heterocyclyl comprising carbon atoms and 1-4 heteroatoms selected from N, NR3a, O, S and substituted with 0 -3 Re; R3a is independently selected from H, C1-4 alkyl, - (CH2) n-aryl substituted with 0-3 Re and - (CH2) n-heterocyclyl substituted with 0-3 Re; R4 is independently selected from C1-5 alkyl substituted with 0-3 Re, (CH2) n-C3-6 carbocyclyl substituted with 0-3 Re and - (CH2) n-heterocyclyl substituted with 0-3 Re; Ra, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, - (CH2) n-C3-10 carbocyclyl substituted with 0-5 Re, and - (CH2) n-heterocyclyl substituted with 0 -5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re; Rb, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, - (CH2) n -C3-10 carbocyclyl substituted with 0-5 Re and - (CH2) n-heterocyclyl substituted with 0-5 Re; Rc, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, C3-6 carbocyclyl and heterocyclyl; Re, in each case, is independently selected from C1-6 alkyl (optionally substituted with halogen, OH and CN), C2-6 alkenyl, C2-6 alkynyl, - (CH2) n-C3-6 cycloalkyl, - (CH2) n-C4-6 heterocyclyl, - (CH2) n-aryl, - (CH2) n- heteroaryl, F, Cl, Br, CN, NO2, = O, CO2H, - (CH2) nORf, S (O) pRf, C (= O) NRfRf, NRfC (= O) Rf, S (O) pNRfRf, NRfS (O) pRf, NRfC (= O) ORf, OC (= O) NRfRf and - (CH2) nNRfRf; Rf, at each occurrence, is independently selected from H, C1-5 alkyl (optionally substituted with halogen and OH), C3-6 cycloalkyl, and phenyl; n is independently selected from zero, 1, 2, and 3; and p, in each case, is independently selected from zero, 1, and 2. |
| priorityDate | 2015-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 708.