| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25c4fc4e202922a16436d7d118f2043e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-626
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-66 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2012-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc4b64007e54b91653b910f84009858a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5171e3d3158e7876675c51a49ad5504f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5616bfedb52dbc66166e19b844150d23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16f3c19f74d60f70758a62524c9253f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f636b94955662fcecbc93bced23d6a1d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa16a2d9b67c35796ee72e8a233d0968
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c0f16accb48d5c8ed3c62caa4321b95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ac016af4a92483258f40d034f76ba15 |
| publicationDate |
2021-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2857734-T3 |
| titleOfInvention |
Bispecific T-cell activating antigen-binding molecules |
| abstract |
A T-cell activating bispecific antigen-binding molecule comprising a first and a second antigen-binding moiety, one of which is a Fab molecule that can specifically bind to CD3 and the other is a Fab molecule that can bind specifically to a target cell antigen, and an Fc domain composed of first and second subunits that can be stably associated; wherein the first antigen-binding moiety is a cross-linking Fab molecule in which the variable or constant regions of the Fab light chain and the Fab heavy chain are exchanged; and wherein (i) the second antigen-binding moiety is fused at the C-terminus of the Fab heavy chain to the N-terminus of the Fab heavy chain of the first antigen-binding moiety, and the first antigen-binding moiety antigen is fused at the C-terminus of the Fab heavy chain to the N-terminus of the first or second subunit of the Fc domain, or (ii) the first antigen-binding moiety is fused at the C-terminus of the Fab heavy chain to the N-terminus of the Fab heavy chain of the second antigen-binding moiety and the second antigen-binding moiety is fused at the C-terminus of the Fab heavy chain to the N-terminus of the first or second subunit of the Fc domain. |
| priorityDate |
2011-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |