abstract |
A composition for use in treating subjects in need of hematopoietic stem cell transplantation, comprising: a population of hematopoietic stem cells treated with a TAT-MYC fusion protein, a TAT-Bcl-2 fusion protein, or both , for 10 minutes to 24 hours, in which the reconstitution of the hematopoietic compartment is enhanced in the subject compared to the reconstitution of the hematopoietic compartment in a subject administered a population of hematopoietic stem cells that were not treated with the composition. |