| abstract |
A compound of formula I or II: ** (See formula) ** in which: L is selected from -NHC (O) - and -C (O) NH-; Y1 is selected from N and CH; R1 is selected from H, halo, isopropyl, methyl-sulfonyl, OR6, NR5R6, methoxy-ethoxy, 2-oxa-5-azabicyclo [2.2.1] heptan-5-yl, 3-oxa-8-azabicyclo [3.2. 1] octan-8-yl, 8-oxa-3-azabicyclo [3.2.1] octan-3-yl, 2-oxo-1,2-dihydropyridin-4-yl, tetrahydro-2H-pyranyl, 4-oxopyridine- 1 (4H) -yl, pyrazolyl, pyridazinyl, and azetidinyl; wherein said azetidinyl, pyrazolyl or 2-oxo-1,2-dihydropyridin-4-yl is unsubstituted or substituted with 1 to 3 groups independently selected from methyl and hydroxy; R2 is selected from H and methyl; R3 is selected from H, methyl, and amino; R4 is selected from: ** (See formula) ** where ** (See formula) ** indicates the point of attachment with L; R5 is selected from H and methyl; R6 is selected from H and methyl, ethyl, propyl, isopropyl, cyclopropyl, methoxy, hydroxyethyl, methoxyethyl, tetrahydro-2Hpyranyl, pyridinyl, tetrahydrofuranyl, and oxetanyl; or R5 and R6, together with the nitrogen to which R5 and R6 are attached, form a group selected from morpholino, 2-oxopyridin-1 (2H) -yl, 1,1-dioxydothiomorpholino, piperazinyl, pyrrolidinyl, imidazolyl and pyrazolyl; wherein said morpholino, pyrazolyl or imidazolyl may be unsubstituted or substituted with 1 to 2 methyl groups; R7 is selected from H, methyl, -CF3, -C (CH3) 2CN, -C (CH3) 2OH, -C (CH3) 2F, -CF2CH3, -CF2H, isopropyl, cyclopropyl, and methyl sulfonyl; wherein said cyclopropyl is unsubstituted or substituted with cyano; R8 is selected from H, methyl, ethyl, isopropyl, -C (CH3) 2OH and -C (CH3) 2NH2; R9 is selected from H and ethyl; or the compound is N- (3- (2-chloro-5-cyanopyridin-3-yl) -4-methylphenyl) -2- (2-cyanopropan-2-yl) isonicotinamide or a pharmaceutically acceptable salt thereof. |