| abstract |
Compound of formula I: ** (See formula) ** or a pharmaceutically acceptable amino acid salt, solvate or conjugate thereof, wherein: R1 is hydroxyl, R2 is hydrogen, hydroxyl, alkyl or halogen, wherein said alkyl is unsubstituted or substituted with one or more Ra, R3 is hydrogen, hydroxyl, alkyl or halogen, wherein said alkyl is unsubstituted or substituted with one or more Rb, R4 is alkyl, alkenyl, alkynyl or halogen, wherein said alkyl is unsubstituted or substituted with one or more Rc, Ra, Rb and Rc are each independently halogen or hydroxyl, R5 is hydroxyl, OSO3H, OSO3-, OCOCH3, OPO3H2, OPO32-, or hydrogen, and R6 is hydroxyl, OSO3H, OSO3-, OCOCH3, OPO3H2, OPO32-, or hydrogen, or together, R5 and R6 together with the carbon atom to which they are attached, form a carbonyl, for use in the treatment or prevention of a gastrointestinal disease selected from inflammatory bowel disease (IBD), irritated bowel syndrome ble (IBS), bacterial overgrowth, malabsorption, posttradiation colitis, and microscopic colitis. |