| abstract |
A method for preparing a compound of formula (A): ** (See formula) ** or a salt or solvate thereof, comprising the steps of: (a) carboxylating a compound of formula (E) or a salt thereof : ** (See formula) ** under sufficient reaction conditions to form a compound of formula (D) or a hydrate, solvate or salt thereof: ** (See formula) ** (b) chlorinate a compound of formula ( D) or a hydrate, solvate or salt thereof under sufficient reaction conditions to form a compound of formula (B) or a salt thereof: ** (See formula) ** and (c) contacting a compound of formula (B) or a salt thereof with a compound of formula (C) or a salt thereof: ** (See formula) ** under sufficient reaction conditions to produce a compound of formula (A). |