| abstract |
A compound having the formula (I): ** (See formula) ** wherein R1 and R2 are each members independently selected from the group consisting of H, halogen, CN, C1-4 alkyl, C1-4 alkoxy and C1-4 haloalkyl; R3a is a member selected from the group consisting of methyl, ethyl, propyl, isopropyl, trifluoromethyl, CH2CF3, and CF2CF3; R3b is a member selected from the group consisting of H and D; R4 is a member selected from the group consisting of H, C1-8 alkyl, -Y, and C1-4 alkylene-Y; wherein Y is aryl or heteroaryl, and each R4 is optionally substituted with from one to four substituents selected from the group consisting of halogen, -CN, -CO2Ra, - CONRaRb, -C (O) Ra, -OC (O) NRaRb, NRaC (O) Rb, - NRaC (O) 2Rc, -NRaC (O) NRaRb, -NRaRb, -ORa, -S (O) 2NRaRb, -NRaS (O) 2Rb, and -Rc, in which each Ra and Rb are independently selected from hydrogen, C1-4 alkyl, C1-4 hydroxyalkyl, and C1-4 haloalkyl, and Rc is selected from C1-4 alkyl, hydroxyalkyl, and C1-4 haloalkyl; R5a and R5b are each members independently selected from the group consisting of H, halogen, C1-4 alkyl, C1-4 alkoxy, and CN; R6a and R6b are each members independently selected from the group consisting of H, C1-4 alkyl, C1-4 hydroxyalkyl, and C1-4 haloalkyl; or optionally R6a and R6b are taken together to form oxo (= O); X is CH or N; or any salts, solvates, hydrates, N-oxides, tautomers or rotamers thereof. |