abstract |
An imaging agent comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, ** (See formula) ** wherein Z1, Z2, Z3 and Z4 are each CH; R1 is selected from aryl, heteroaryl, and heterocycloalkenyl, each of which is optionally substituted with one or two groups independently chosen from alkynyl, heteroaryl, cyano, optionally substituted amino, halo, C1-6 alkyl, and amino-substituted C1-6 alkyl. optionally substituted; L1 is O; L2 is (CH2) m where m is 0, 1 or 2; and R2 is selected from aryl, aryl substituted with hydroxyl or C1-6 alkoxy, heteroaryl and heteroaryl substituted with hydroxyl or C1-6 alkoxy, R5 is selected from C1-6 alkyl, C1-6 alkoxy, halo and oxo (as a substituent in the heterocycloalkyl ring); and n is 0 or 1; wherein the compound of Formula I or a pharmaceutically acceptable salt thereof, is labeled with one or more positron emitting radionuclides. |