http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2841548-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_872dd7cd609eb2a937dcfd303d521798 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-86 |
| filingDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acdd1a092aec67d59cba99c617d61338 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b167d68d9c3efe872b1d83b7b5dc8276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b063abf609eaa4fea11f8e9a0f2c619 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2669b3134178f70e89310593880934a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5eeb4562725406ef42ed2c3627593c1f |
| publicationDate | 2021-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2841548-T3 |
| titleOfInvention | Protac compounds that modulate RIP2 kinase activity |
| abstract | A compound that is (S) -7- (2- (2- (2- (2 - ((4- (Benzo [d] thiazol-5-ylamino) -6- (tert-butylsulfonyl) quinolin-7-yl ) oxy) ethoxy) ethoxy) ethoxy) ethoxy) -2 - ((S) -3,3-dimethyl-2 - ((S) -2-methylamino) propanamido) butanoyl) -N - ((R) -1, 2,3,4-tetrahydronaphthalen-1-yl) -1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (S) -7- (2- (2- (2- (2 - ((4- (Benzo [d] thiazol-5-ylamino) -6- (tert-buylsulfonyl) quinolin-7-yl) oxy) ethoxy ) ethoxy) ethoxy) ethoxy) -2 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((S) -1,2,3 , 4-tetrahydronaphthalen-1-yl) -1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (S) -7- (2- (2- (2- (2 - ((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin- 7-yl) oxy) ethoxy) ethoxy) ethoxy) ethoxy) -2 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R ) -1,2,3,4-tetrahydronaphthalen-1-yl) -1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (2S, 4S) -4- (14 - ((4- (benzo [d] thiazol-5-ylamino) -6- (tert-buylsulfonyl) quinolin-7-yl) oxy) -3,6,9,12 -tetraoxatetradecanamido) -1- ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R) -3-methylbutan-2-yl) pyrrolidin -2-carboxamide, - (2S, 4S) -4- (14 - ((4- (benzo [d] thiazol-5-ylamino) -6- (tert-buylsulfonyl) quinolin-7-yl) oxy) -3 , 6,9,12-tetraoxatetradecanamido) -1- ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R) -1.2 , 3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (2S, 4S) -4- (14 - ((4- (benzo [d] thiazol-5-ylamino) -6- (tert-buylsulfonyl) quinolin-7-yl) oxy) -3,6,9,12 -tetraoxatetradecanamido) -N- ((R) -2,3-dihydro-1H-inden-1-yl) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino ) propanamido) butanoyl) pyrrolidine-2-carboxamide; (2S, 4S) -4- (14 - ((4- (benzo [d] thiazol-5-ylamino) -6- (tert-buylsulfonyl) quinolin-7-yl) oxy) -3,6,9,12 -tetraoxatetradecanamido) -1- ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R) -1-phenylpropyl) pyrrolidine-2-carboxamide ; (2S, 4S) -4- (14 - ((4- (benzo [d] thiazol-5-ylamino) -6- (tert-butylsulfonyl) quinolin-7-yl) oxy) -3,6,9,12 -tetraoxatetradecanamido) -N- (2,6-difluorophenyl) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) pyrrolidine-2-carboxamide; (2S, 4S) -4- (2- (2- (2- (2 - ((6- (Tert-butylsulfonyl) -4 - ((5-fluoro-1H-indazol-3-yl) amino) quinolin- 7-yl) oxy) ethoxy) ethoxy) ethoxy) ethoxy) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R ) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (2S, 4S) -4- (2- (2- (2 - ((6- (Tert-buylsulfonyl) -4 - ((5-fluoro-1H-indazol-3-yl) amino) quinolin-7-yl ) oxy) ethoxy) ethoxy) ethoxy) -1 - ((S) - 3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R) -1.2 , 3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; 5- (4- (2 - ((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) ethyl) piperazin- 1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - (((R) - 1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) pyrazine-2-carboxamide; 2- (4- (2 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) ethyl) piperazin- 1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - (((R) - 1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3- yl) pyrimidine-5-carboxamide 5- (4 - (((6- (tert-buylsulfonyl) -4 - ((4,5 -dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) methyl) piperidin-1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl- 2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - (((R) -1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) pyrazin-2 -carboxamide; 6- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperidin- 1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - (((R) - 1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) nicotinamide; 2- (4 - (((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) methyl) piperidin-1- yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - (((R) -1, 2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) pyrimidine-5-carboxamide; 6- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperazine- 1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - (((R) - 1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) nicotinamide; 5- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperazine- 1-yl) -N - ((35.55) -1- ((5) -2-cyclohexyl-2 - ((5) -2- (methylamino) propanamido) acetyl) -5 - (((R) - 1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) pyrazine-2-carboxamide; 2- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperazine- 1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - (((R) - 1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) pyrimidine-5-carboxamide; 5- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperazine- 1-yl) -N - ((3S, 5S) -1- ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -5 - (((R ) -1,2,3,4-tetrahydronaphthalen-1-yl) carbamoyl) pyrrolidin-3-yl) pyrazine-2-carboxamide; (2S, 4S) -4 - ((2- (4- (2 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-10 pyrazol-3-yl) amino) quinazolin -7-yl) oxy) ethyl) piperazin-1-yl) pyrimidin-5-yl) oxy) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido ) butanoyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide, 2- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperazin-1-yl) -N - ((3S, 5S) -5- ((2 , 6-Difluorophenyl) carbamoyl) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) bufanoyl) pyrrolidin-3-yl) pyrimidine-5-carboxamide; 2- (4- (2 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) ethyl) piperazin- 1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - ((3-methyl- 1-phenyl-1H-pyrazol-5-yl) carbamoyl) pyrrolidin-3-yl) pyrimidine-5-carboxamide; 2- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperazine- 1-yl) -N - ((3S, 5S) -1- ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -5 - ((3-methyl- 1-phenyl-1H-pyrazol-5-yl) carbamoyl) pyrrolidin-3-yl) pyrimidine-5-carboxamide; (S) -7 - ((6- (4 - ((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy ) piperidin-1-yl) pyrimidin-4-yl) oxy) -2 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - (( R) -1,2,3,4-tetrahydronaphthalen-1-yl) -1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (S) -7 - ((6- (4 - (((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) methyl) piperidin-1-yl) pyrimidin-4-yl) oxy) -2 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) -1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (2S, 4S) -4 - ((2- (4 - (((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7- yl) oxy) methyl) piperidin-1- yl) pyrimidin-5-yl) oxy) -1 - ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (2S, 4S) -4 - ((2- (4 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl ) oxy) piperidin-1-yl) pyrimidin-5-yl) oxy) -1 - ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -N - (( R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (2S, 4S) -4 - ((2- (4- (2 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin- 7-yl) oxy) ethyl) piperazin-1- yl) pyrimidin-5-yl) oxy) -1 - ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide, (2S, 4S) -4 - ((2- (4- (2 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) ethyl) piperidin-1-yl) pyrimidin-5-yl) oxy) -1 - ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (2S, 4S) -4 - ((2- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin- 7-yl) oxy) propyl) piperidin-1- yl) pyrimidin-5-yl) oxy) -1 - ((S) -2-cyclohexyl-2 - ((S) -2- (methylamino) propanamido) acetyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (2S, 4S) -4 - ((2- (4- (2 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin- 7-yl) oxy) ethyl) piperazin-1-yl) pyrimidin-5-yl) oxy) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- (methylamino) propanamido) butanoyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (2S, 4S) -4 - ((2- (4- (2 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin- 7-yl) oxy) ethyl) piperazin-1-yl) pyrimidin-5-yl) oxy) -N- (2,6-difluorophenyl) -1 - ((S) -3,3-dimethyl-2 - (( S) -2- (methylamino) propanamido) butanoyl) pyrrolidine-2-carboxamide; 2- (4- (2 - ((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) ethyl) piperazin- 1-yl) -N - ((3S, 5S) -5- ((2,6-difluorophenyl) carbamoyl) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- ( methylamino) propanamido) butanoyl) pyrrolidin-3-yl) pyrimidine-5-carboxamide; 5- (4- (3 - ((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7-yl) oxy) propyl) piperazine- 1-yl) -N - ((3S, 5S) -5 - ((2,6-difluorophenyl) carbamoyl) -1 - ((S) -3,3-dimethyl-2 - ((S) -2- ( methylamino) propanamido) butanoyl) pyrrolidin-3-yl) pyrazine-2-carboxamide; (S) -1 - ((S) -2- (1- (2- (4- (2 - ((6- (Tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazole-3 -yl) amino) quinazolin-7-yl) oxy) ethyl) piperazin-1- yl) pyrimidine-5-carbonyl) piperidin-4-yl) -2 - ((S) -2- (methylamino) propanamido) acetyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (S) -1 - ((S) -2- (1- (2- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazole-3 -yl) amino) quinazolin-7-yl) oxy) propyl) piperazin-1- yl) pyrimidine-5-carbonyl) piperidin-4-yl) -2 - ((S) -2- (methylamino) propanamido) acetyl) -N - ((R) -1,2,3,4-tetrahydronaphthalen-1-yl) pyrrolidine-2-carboxamide; (5S, 8S, 10aR) -N-Benzhydryl-3- (5- (4 - (((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) ) quinazolin-7-yl) oxy) methyl) piperidin-1-yl) pyrazine-2-carbonyl) -5 - ((S) -2- (methylamino) propanamido) -6-oxodecahydropyrrolo [1,2- a] [ 1,5] diazocin-8-carboxamide; (5S, 8S, 10aR) -3- (5- (4 - (((6- (tert-butylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin-7 -yl) oxy) methyl) piperidin-1- yl) pyrazine-2-carbonyl) -5 - ((S) -2- (methylamino) propanamido) -6-oxo-N - ((R) -1.2, 3,4-tetrahydronaphthalen-1-yl) decahydropyrrolo [1,2-a] [1,5] diazocin-8-carboxamide; (5S, 8S, 10aR) -3- (5- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin) -7-yl) oxy) propyl) piperazin-1-yl) pyrazine-2-carbonyl) -5 - ((S) -2- (methylamino) propanamido) -6-oxo-N - ((R) -1, 2,3,4-tetrahydronaphthalen-1-yl) decahydropyrrolo [1,2-a] [1,5] diazocin-8-carboxamide; (5S, 8S, 10aR) -3- (2- (4- (3 - ((6- (tert-buylsulfonyl) -4 - ((4,5-dimethyl-1H-pyrazol-3-yl) amino) quinazolin) -7-yl) oxy) propyl) piperazin-1-yl) pyrimidine-5-carbonyl) -5 - ((S) -2- (methylamino) propanamido) -6-oxo-N - ((R) -1, 2,3,4-tetrahydronaphthalen-1-yl) decahydropyrrolo [1,2-a] [1,5] diazocin-8-carboxamide; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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