| abstract |
Compound of formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate or a pharmaceutically acceptable salt thereof ** (See formula) ** in which: U is phenyl; each R1 and R2 is independently H, D, halogen, OH, NH2, NO2, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 haloalkylamino, 3-8 membered cycloalkyl or 3-8 membered heterocyclyl, wherein each of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 haloalkylamino, 3-8 membered cycloalkyl or 3-8 membered heterocyclyl is independently and optionally substituted with 1, 2, 3, 4 or 5 selected substituents from OH, oxo (= O), NH2, NO2 or CN; T is H, D, F, Cl, Br, NO2, CN or CF3; X is CR4 or N; R4 is H, D, halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy; Y and Z are each independently C, CH, or N; "" refers to a single bond or a double bond; Q is pheno, C4-7 carbocycle, 4-7 membered heterocycle, or 5-6 membered heteroaromatic ring; each R3 is independently H, D, halogen, oxo (= O), OH, NH2, NO2, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, haloalkoxy C 1-6, C 1-6 alkylamino, C 1-6 haloalkylamino, 3- to 8-membered cycloalkyl, 3- to 8-membered heterocyclyl, 5 to 10-membered heteroaryl, phenyl, naphthyl, or G, wherein each of C 1-6 alkyl 6, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 haloalkylamino, 3-8 membered cycloalkyl, 3-8 membered heterocyclyl or 5 to 10 membered heteroaryl is independently and optionally substituted with 1, 2, 3, 4 or 5 substituents selected from OH, oxo (= O), NH2, NO2, CN or G; G is C1-6 substituted aliphatic hydrocarbon, wherein each of the methylene groups of the C1-6 aliphatic hydrocarbon is optionally and independently substituted with J; J is -NH-, -S-, -O-, -C (= O) -, -C (= O) NH-, -SO-, -SO2-, -NHC (= O) -, -C ( = O) O-, -SO2NH- or -NHC (= O) NH-; m is 0, 1, 2, or 3; and n is 0, 1, 2, 3, or 4; with the proviso that: (1) when T is F, Cl, Br or CF3, R1 is OH; (2) when T is H, ** (See formula) ** is ** (See formula) ** and Q is not pheno; (3) when T is NO2, R1 is not H. |