| abstract |
Use of a glycosaminoglycan derivative to inhibit heparanase, in which the glycosaminoglycan derivative contains di- or tricarboxylated residues and / or is obtained by a process that comprises: a) oxidation from 10% to 100%, of non-sulphated residues in 2-O- and optionally 2N-, 3-O-, of a glycosaminoglycan, under conditions effective to convert adjacent diols and optionally adjacent OH / NH2 into dialdehydes; b) the oxidation of the oxidized glycosaminoglycan under effective conditions to convert said dialdehydes into carboxylate groups, where the glycosaminoglycan is a natural or synthetic glycosaminoglycan, selected from heparin, low molecular weight heparins, heparan sulfate, optionally 2-O- and / or 2-N-desulphated, where the use does not comprise treatment of the human or animal body. |