http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2835065-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10 |
| filingDate | 2016-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96486157fac236dc92c3d894835e3e18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dea843fe4557f3629368205c9405a7c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26af1d3be53ce309af2169b415eb6006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e29c76ab29b585bd880ecca6757dcf98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bf4821f7a22f98b6fc990d11e83e120 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8793e6319adb328d35dcb34993e823e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5de32e3c484a068301c9d6fb5723eaf |
| publicationDate | 2021-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2835065-T3 |
| titleOfInvention | Contrast agents |
| abstract | A compound of formula (I) ** (See formula) ** in which: R is -CH (R1) -COOH, in which: R1 is H or a C1-C3 alkyl chain that is optionally substituted with a C1-C3 alkoxy or C1-C3 hydroxyalkoxy group; n is 1 or 2; Z is an amine derivative selected from -N (R2) (R3) and -NHR4; wherein: R2 is selected from the group consisting of: an aryl ring, a cycloalkyl ring, and a C1-C10 alkyl optionally interrupted by one or more oxygen atoms and / or optionally substituted with one or more hydroxyl groups, or with an aryl or cycloalkyl ring; R3 is selected from the group consisting of: a C5-C12 hydroxyalkyl comprising at least 2 hydroxyl groups; a C2-C10 hydroxyalkoxyalkylene of the formula - (CH2) r - [(O- (CH2) r] m (CH2) sOH; and a group of the formula - (CH2) sCH (R5) -G; where s is 0 , 1 or 2; r is, independently of each other, 1 or 2; m is 1, 2 or 3; and wherein R5 is H, or an arylalkylene or cycloalkyl-alkylene having up to 3 carbon atoms in the chain alkylene; G is a group selected from -PO (OR6) 2, -PO (R7) (OR6) and -COOH; wherein R6, independently of one another, is H or C1-C5 alkyl; R7 is a aryl or cycloalkyl ring, or C1-C5 alkyl which is optionally substituted with an aryl or cycloalkyl ring, or R2 and R3, together with the connecting nitrogen atom, form a substituted five or six membered heterocyclic ring; R4 is selected from the group consisting of: a C5-C12 hydroxyalkyl comprising at least 2 hydroxyl groups, a C2-C10 hydroxyalkoxyalkylene of formula - (CH2) r - [(O- (CH2) r] m (CH2) sOH; - (CH2) mPO (OR6) 2; - (CH2) mPO (R7) (OR6); and - (CH2) sCH (R8) G; where: R8 is an arylalkylene or cycloalkyl-alkylene having up to 3 carbon atoms in the alkylene chain; and m, r, s, R6 and R7 are as indicated above. as well as individual diastereoisomers and their racemic mixtures, geometric isomers and resolved enantiomers thereof, and the physiologically acceptable salt thereof. |
| priorityDate | 2015-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 152.