http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2834470-T3
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97880c2aedd9e60389fe06a6e6f45f24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae92cda05f17ef26b3814081e392849c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56966 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-403 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2013-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94b4bac9d1706f762c9d81e02db11a7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb868992831ebddbf442fe5d5334eddc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e6f861e20cabb195fa4f58f1759f40c |
| publicationDate | 2021-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2834470-T3 |
| titleOfInvention | Protein marking compound |
| abstract | A complex, for use in an in vivo method of cell labeling to discriminate, in a population of cells, between living cells and cells whose plasma membrane has lost its integrity, such as dead cells; of a first compound and a first protein of the cell whose plasma membrane has lost its integrity, in which the first compound is applied extracellularly without being activated and is substantially incapable of crossing a healthy cell membrane; wherein this first compound is selected from one or more than one fluorescent compound, being a cyanine, and a conjugate thereof of which, preferably a non-activated or deactivated compound, such as a carboxylate thereof; where the first protein is selected from the group consisting of: fibrous proteins, fibrous structural proteins, metalloenzymes, Hsp90p co-companion (CDC37), isomers thereof, complexes thereof, and their decomposition products, where the first compound and the first protein interacts chemically / physically / biologically, where discrimination is performed by marking cells whose plasma membrane has lost its integrity and performing a measurement to quantify the interaction between the first compound and the cell whose plasma membrane has lost integrity , and by (e) performing one or more additional measurements on the sample with a suitable first technique to detect the first compound to obtain a value or values of the first compound, (f) additionally determining an amount of interaction by analyzing the value or values to determine one or more values of one or more parameters of the biological sample, of that s cells whose plasma membrane has lost its integrity, where a value or values above a threshold value indicate the binding of the compound to the first cellular protein. |
| priorityDate | 2012-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467774809 |
Total number of triples: 31.