http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2832893-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-147 |
filingDate | 2016-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b14063a157ea005b9f45a08e4cc8ba2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_354abf02afa53839ff36e868061b29d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18a18bfc9c44bb885d38afb9b281632e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0409a702f1d3f4db17e047ca6365af7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67552b7b38aea238f899d93ce62fa988 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec79cce349dba23158f6e654ca9eb17a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82694e3f0301ec8f114448cdaa5bdd9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b08f2cc7348207eb00f0fc825ecd246 |
publicationDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2832893-T3 |
titleOfInvention | Tricyclic compounds and their use as phosphodiesterase inhibitors |
abstract | A compound of formula I: ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: Ring A is an oxygen-containing fused heterocycloalkyl ring (4 to 8 membered), a fused phenyl ring or a nitrogen-containing fused heteroaryl ring (5 to 8 membered) and, where chemically permissible, oxygen-containing fused heterocycloalkyl ring (4 to 8 membered), fused phenyl ring and nitrogen-containing fused heteroaryl ring (of 5 to 8 members) are optionally substituted with one to six R8, provided that the fused phenyl ring is not substituted with chlorine, bromine, nitro or methoxy; R1 is selected from the group consisting of (C3-C8) cycloalkyl, heterocycloalkyl (4 to 10 membered), (C6-C10) aryl, and heteroaryl (5 to 14 membered) and, when chemically permissible, cycloalkyl moieties (C3-C8), heterocycloalkyl (4 to 10 membered), aryl (C6-C10) and heteroaryl (5 to 14 membered) are optionally substituted with one to six R9; R2 is selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C15) alkyl -OR5, -C (= O) -R5, -C (= O) -OR5, -C (= O) -N (R5) (R6), - (SO2) R5, cycloalkyl (C3-C8), heterocycloalkyl (4 to 10 membered), aryl (C6- C10) and heteroaryl (5 to 14 membered) and, when chemically permissible, alkyl (C1-C6), alkenyl (C2-C6), alkynyl (C2-C6), cycloalkyl (C3-C8), heterocycloalkyl (of 4 to 10 membered), aryl (C6-C10) and heteroaryl (5 to 14 membered) are optionally substituted with one to six R8; R3a, when chemically permissible, is selected from the group consisting of hydrogen, halogen, oxo, cyano, hydroxy, -SF5, nitro, N (R5) (R6), optionally substituted alkylthio (C1-C6), alkyl (C1 -C6) optionally substituted, optionally substituted (C1-C6) alkoxy and optionally substituted (C3-C8) cycloalkyl or R2 and R3a, taken together with the nitrogen and carbon atoms to which they are attached, form a heterocycloalkyl ring (from 4-6 membered) and, where chemically permissible, the heterocycloalkyl ring (4-6 membered) is optionally substituted with one to six R8; when present, R3b is selected from the group consisting of hydrogen, halogen, oxo, cyano, hydroxy, -SF5, nitro, N (R5) (R6), optionally substituted (C1-C6) alkylthio, (C1-C6) alkyl optionally substituted, optionally substituted (C1-C6) alkoxy and optionally substituted (C3-C8) cycloalkyl or R3a and R3b, taken together with the carbon atom to which they are attached, form a (C3-C6) cycloalkyl or a heterocycloalkyl (from 4 to 6 membered) and, where chemically permissible, cycloalkyl (C3-C6) or heterocycloalkyl (4 to 6 membered), when chemically permissible, are optionally substituted with one to six R8. R4a, when chemically permissible, is selected from the group consisting of hydrogen, halogen, oxo, cyano, hydroxy, -SF5, nitro, N (R5) (R6), optionally substituted alkylthio (C1-C6), alkyl (C1 -C6) optionally substituted and optionally substituted (C1-C6) alkoxy; when present, R4b is selected from the group consisting of hydrogen, halogen, oxo, cyano, hydroxy, -SF5, nitro, N (R5) (R6), optionally substituted (C1-C6) alkylthio, (C1-C6) alkyl optionally substituted and optionally substituted (C1-C6) alkoxy or R4a and R4b, taken together with the carbon atom to which they are attached, form a (C3-C6) cycloalkyl or a (4-6 membered) heterocycloalkyl and, where applicable chemically permissible, cycloalkyl (C3-C6) or heterocycloalkyl (4-6 membered) are optionally substituted with one to six R8; each of R5 and R6, each occurrence, is independently selected from the group consisting of hydrogen and (C1-C6) alkyl; R7 is (C1-C6) alkyl; when present, R8, at each occurrence, is independently selected from the group consisting of halogen, oxo, cyano, hydroxy, -SF5, nitro, N (R5) (R6), optionally substituted (C1-C6) alkylthio, optionally substituted (C1-C6) alkyl and optionally substituted (C1-C6) alkoxy; when present, R9, at each occurrence, is independently selected from the group consisting of halogen, oxo, cyano, hydroxy, -SF5, nitro, optionally substituted (C1-C6) alkyl, optionally substituted (C2-C6) alkenyl , optionally substituted (C2-C6) alkynyl, optionally substituted (C1-C6) alkylthio, optionally substituted (C1-C6) alkoxy, -N (R5) (R6), -N (R5) (C (O) R6), -C (= O), -C (= O) -R5, -C (= O) -OR5, - (SO2) R7 and -S (= O2) N (R5) (R6); ------ is absent (forming a single bond) or a bond (forming a double bond) and n is an integer selected between 0 or 1, with the condition that when ------ is present to form a double bond then n is 0 and when ------ is absent to form a single bond n is 1. |
priorityDate | 2015-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 2899.