| abstract |
Multivalent immunogenic composition, comprising: 13 different polysaccharide-protein conjugates, together with a physiologically acceptable carrier, in which each of the polysaccharide-protein conjugates comprises a capsular polysaccharide of a different serotype of Streptococcus pneumoniae conjugated to the carrier protein CRM197, and capsular polysaccharides are prepared from 12 serotypes selected from the group consisting of 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, and serotype 2 or 9N. |