http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2831162-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39bf0bb8b07e151d4bcead749d7dd699 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558 |
| filingDate | 2016-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78d156ee027c0a3d91d7750d882f6296 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63a83c5f48f9f4c6bb645087862ebd3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faf55678bdb4622a8a1cd702d38772cd |
| publicationDate | 2021-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2831162-T3 |
| titleOfInvention | Phospholipidation of imidazoquinolines and oxoadenines |
| abstract | A process for the preparation of a compound of formula (I), comprising the steps of: a) reacting a compound of formula (III): ** (See formula) ** in which n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20; R2 is H or a C4-C24 linear or branched, optionally unsaturated alkyl or a C4-C24 linear or branched, optionally unsaturated acyl and R3 is a C4-C24 linear or branched, optionally unsaturated alkyl or a C4-C24 linear or branched acyl , optionally unsaturated; with a compound of formula (V): ** (See formula) ** wherein GP is a suitable protecting group for hydroxyl protection, including but not limited to cyanoethyl, methyl, ethyl, benzyl and allyl groups ; to prepare a compound of formula (VI): ** (See formula) ** wherein R = ** (See formula) ** b) reacting a compound of formula (VI) with a compound of formula (VII) : ** (See formula) ** wherein R1 is selected from H, C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C3-6 cycloalkyl-C1-6 alkyl, C3-6 cycloalkyl-C1 alkylamino -6, C3-6 cycloalkyl-C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkoxy-C1-6 alkylamino and C1-6 alkoxy-C1-6 alkoxy; wherein C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C3-6 cycloalkyl-C1-6 alkyl, C3-6 cycloalkyl-C1-6 alkylamino, C3-6 cycloalkyl-C1-6 alkoxy, C1-6 alkoxy -6-C1-6 alkyl, C1-6 alkoxy-C1-6 alkylamino or C1-6 alkoxy-C1-6 alkoxy are branched or unbranched and optionally terminally substituted with a hydroxyl, amino, thio, hydrazino, hydrazido, azido group , acetylenyl, carboxyl, or maleimido and Z is selected from C2-C6 alkyl and C2-C6 alkenyl, wherein C2-C6 alkyl or C2-C6 alkenyl are unsubstituted or terminally substituted with - (O-C2-C6 alkyl) 1-6-; to prepare a compound of formula (IX); ** (See formula) ** where GP is a suitable protecting group for hydroxyl protection, including, but not limited to, cyanoethyl, methyl, ethyl, benzyl, and allyl groups; R = ** (See formula) ** R '= ** (See formula) ** wherein R1 is selected from H, C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C3-6 cycloalkyl- C1-6 alkyl, C3-6 cycloalkyl-C1-6 alkylamino, C3-6 cycloalkyl-C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, C1-6 alkoxy-C1-6 alkylamino and C1-6 alkoxy C1-6 alkoxy; wherein C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C3-6 cycloalkyl-C1-6 alkyl, C3-6 cycloalkyl-C1-6 alkylamino, C3-6 cycloalkyl-C1-6 alkoxy, C1-6 alkoxy -6-C1-6 alkyl, C1-6 alkoxy-C1-6 alkylamino or C1-6 alkoxy-C1-6 alkoxy are branched or unbranched and optionally terminally substituted with a hydroxyl, amino, thio, hydrazino, hydrazido, azido group , acetylenyl, carboxyl, or maleimido and Z is selected from C2-C6 alkyl and C2-C6 alkenyl, wherein C2-C6 alkyl or C2-C6 alkenyl are unsubstituted or terminally substituted with - (O-C2-C6 alkyl) 1-6- and c) oxidize a compound of formula (IX) and remove the hydroxyl protecting group to obtain a compound of formula (I): ** (See formula) ** |
| priorityDate | 2015-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID468181860 |
Total number of triples: 21.