http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2830350-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60d2134a44f2b4765a9a1a36828c1d8c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-0102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2408 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 |
| filingDate | 2009-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18a67e7bf123ebb45acc8a8d31ea34d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_439dbfbceb11d7183a7593542199c7d8 |
| publicationDate | 2021-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2830350-T3 |
| titleOfInvention | Lysosomal targeting peptides and uses thereof |
| abstract | A nucleic acid encoding a fusion protein comprising an amino acid sequence at least 70% identical to human wild-type acid alpha-glucosidase (GAA) that still encodes a protein that can rescue or ameliorate one or more symptoms of the lysosomal storage disease; a lysosomal targeting residue, wherein the lysosomal targeting residue is an IGF-II mutein comprising an amino acid sequence at least 70% identical to mature human IGF-II (SEQ ID NO: 1), with a mutation within a region corresponding to amino acids 30-40 of SEQ ID NO: 1 such that said mutation abrogates at least one furin protease cleavage site, where the IGF-II mutein is (a) resistant to furin cleavage, ( b) has decreased binding affinity for the insulin receptor relative to the affinity of naturally-occurring human IGF-II for the insulin receptor and (c) binds to the human cation-independent mannose-6-phosphate receptor in a independent of mannose-6-phosphate. |
| priorityDate | 2008-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 283.