| abstract |
A T-lymphocyte activating bispecific antigen-binding molecule comprising (i) a first antigen-binding moiety that is a Fab molecule that can specifically bind to CD3, and that comprises at least one amino acid sequence of the region Complementarity determinant (CDR) of the heavy chain selected from the group consisting of SEQ ID NO: 37, SEQ ID NO: 38 and SEQ ID NO: 39 and at least one CDR of the light chain selected from the group of SEQ ID NO : 32, SEQ ID NO: 33, SEQ ID NO: 34; (ii) a second antigen-binding moiety that can specifically bind to folate receptor 1 (FolR1); wherein the antigen-binding moiety that can specifically bind to FolR1 comprises: a) the heavy chain CDR1 of SEQ ID NO: 16, the heavy chain CDR2 of SEQ ID NO: 17, the CDR3 of the heavy chain of SEQ ID NO: 18, the CDR1 of the light chain of SEQ ID NO: 32, the CDR2 of the light chain of SEQ ID NO: 33 and the CDR3 of the light chain of SEQ ID NO: 34; b) the CDR1 of the heavy chain of SEQ ID NO: 8, the CDR2 of the heavy chain of SEQ ID NO: 56, the CDR3 of the heavy chain of SEQ ID NO: 57, the CDR1 of the light chain of SEQ ID NO: 59, the light chain CDR2 of SEQ ID NO: 60 and the light chain CDR3 of SEQ ID NO: 65; or c) the CDR1 of the heavy chain of SEQ ID NO: 16, the CDR2 of the heavy chain of SEQ ID NO: 275, the CDR3 of the heavy chain of SEQ ID NO: 315, the CDR1 of the light chain of SEQ ID NO: 32, the light chain CDR2 of SEQ ID NO: 33 and the light chain CDR3 of SEQ ID NO: 34 |