| abstract |
The compound of formula ** (See formula) ** wherein R1 is -NHR2; R2 is C1-C6 alkyl or C3-C8 cycloalkyl; R3 is H, C1-C6 alkyl, C1-C6 hydroxyalkyl or C3-C8 cycloalkyl; R4 is H, C1-C6 alkyl, 3- to 10-membered monocyclic or bicyclic cycloalkyl, 6 to 10-membered monocyclic or bicyclic aryl, 4- to 10-membered monocyclic or bicyclic heterocyclyl, or substituted 4- to 10-membered monocyclic or bicyclic heteroaryl , each heterocyclyl or heteroaryl containing 1-3 heteroatoms selected from N, O and S, any of said groups other than H substituted with 0-4 R7; R5 is H or C1-C4 alkyl; n is 1 or 2; R7 is H, halo, CN, CF3, C1-C4 alkyl, C1-C4 alkoxy, -CONH-C1-C6 alkyl, -CONH-C1-C6 haloalkyl, -CONHhalo C1-C6 alkoxy, heteroaryl, alkynyl (-CCR5), alkenyl-CR5 = C (R5) non-aryl, said aryl and heteroaryl groups substituted with 0-2 R8; R8 is H, halo, CF3, C1-C4 alkyl or C1-C4 alkoxy; or a pharmaceutically acceptable salt thereof. |