| abstract |
A compound that is an arylimidazolyl isoxazole of formula (I): ** (See formula) ** where: R0 and R, which are the same or different, are each H or C1-C6 alkyl that is unsubstituted or substituted with OH, -OC (O) R 'or OR' where R 'is unsubstituted C1-C6 alkyl; W is N or CH; R1 is a group that is unsubstituted or substituted and is selected from 4- to 6-membered heterocyclyl linked to C; C3-C6 cycloalkyl; C1-C6 alkyl which is unsubstituted or substituted with C6-C10 aryl, N-containing 5 to 12-membered heteroaryl, C3-C6 cycloalkyl, OH, -OC (O) R 'or OR' where R 'is as previously defined; and a spiro group of the following formula: ** (See formula) ** is -CH2-, -CH2CH2- or -CH2CH2CH2-; n is 0 or 1; R2 is a group selected from C6-C10 aryl, 5 to 12 membered N-containing heteroaryl, C3-C6 cycloalkyl and C5-C6 cycloalkenyl, wherein the group is unsubstituted or substituted and wherein C6-C10 aryl is optionally fused with a 5- or 6-membered heterocyclic ring; or a pharmaceutically acceptable salt thereof. |