| abstract |
A compound according to formula (II) or pharmaceutically acceptable salts thereof: ** (See formula) ** wherein 0, 1 or 2 of A1, A2, A4 and A5 are independently selected from N and the rest are CR7; R1 represents a group selected from: C1-8 alkyl, C1-8 haloalkyl, C1-8 alkoxy, C2-8 alkyl ether, -C (O) RA, C3-10 carbocyclic group, 3- to 10-membered heterocyclic group, alkyl C1-8 substituted with a C3-10 carbocyclic group and C1-8 alkyl substituted with a 3- to 10-membered heterocyclic group, wherein each of the aforementioned groups is unsubstituted or substituted with 1 to 5 independently selected substituents between: halo, C1-4 alkyl, halo C1-4alkyl, C1-4 alkoxy, C2-4 alkyl ether, -ORA, -NRARB, = O, -OC (O) RA, -C (O) RA, -C (O) ORA, -NRAC (O) RB, -C (O) NRARB, -NRAS (O) 2RB, -S (O) 2NRARB, benzoyl, a 5- or 6-membered heterocycloaryl, a 3-6 heterocycloalkyl ring members, C 1-4 alkyl substituted with -ORA and C 1-4 alkoxy substituted with -ORA or a single R 1 atom is substituted twice so as to form a 3- to 6-membered heterocycloalkyl or cycloalkyl ring; R2 is NH2; R3 is -C (O) NH2; R4a and R4b are H; R5 is H or C1-4 alkyl; R6 is a group selected from one, substituted or unsubstituted, of: phenyl or a 5- or 6-membered heteroaryl ring, wherein, when substituted, R6 contains 1 to 5 independently selected substituents each occurring from: halo , -ORI, -NRIRJ, -CN, C1-6 alkyl, C1-6 haloalkyl and C1-6 alkyl substituted with -ORI; R7 is selected from: H, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1-6 alkyl substituted with -ORH; m is 1; RA and RB are independently selected, each occurrence, from: H, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, phenyl, benzyl or C1-4 alkyl substituted with -ORH; RI and RJ are independently selected each occurrence from: H, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, and -ORH substituted C1-4 alkyl; and RH is selected from H or C1-4 alkyl. |