http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-282708-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d25d299539e76a2d4102de59ff3fc261 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08 |
| filingDate | 1962-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-282708-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF NEW COMPOUNDS WITH HYPOTENSOR ACTIVITY |
| abstract | The invention comprises 2-amino-(mono- or di-substituted)-ethyl guanidines having the formula <FORM:0972888/C1/1> wherein R1 and R2 are different and each is either a hydrogen atom or an alkyl, cycloalkyl or aralkyl group with 1 to 7 carbon atoms, and their addition salts with organic or inorganic acids. The compounds are prepared by condensing the corresponding N1-mono- or N1,N1-di-substituted ethylene diamine dissolved in water or an organic solvent, with cyanamide, its salts, or a compound having the formula <FORM:0972888/C1/2> wherein X is an alkylmercapto, alkyloxy, or pyrazolyl group. Organic solvents which may be employed are alcohols, ethers, ketones and C1-4 aliphatic acids. The reaction may be carried out at room temperature but is preferably carried out at a temperature up to the boiling point of the reaction solvent for 3 to 10 hours. The N1-mono- or N1,N1-di-substituted ethylene diamine starting materials may be prepared by saponifying the corresponding phthalimidoethyl derivatives obtained by reaction of 2-bromoethyl-phthalimide with the appropriate primary or secondary amine. Pharmaceutical compositions for oral or parenteral administration having hypotensive activity comprise the above guanidine compounds together with a pharmaceutically acceptable carrier. The compositions may be formulated as tablets, powders, pills, solutions or suspensions. |
| priorityDate | 1961-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.