| abstract |
An antibody comprising a modified heavy chain constant region, wherein the modified heavy chain constant region comprises a CH1 domain, a hinge, a CH2 domain, and a CH3 domain in order from the N to the C terminus, where: (a ) the hinge comprises the amino acid sequence of SEQ ID NO: 21; (b) the CH1 domain comprises the amino acid sequence of SEQ ID NO: 7; (c) the CH2 domain comprises the amino acid sequence of SEQ ID NO: 4 or the amino acid sequence of SEQ ID NO: 24; and (d) the CH3 domain comprises the amino acid sequence of SEQ ID NO: 5 or SEQ ID NO: 5 with the amino acid substitutions E356D and M358L; or wherein the heavy chain constant region comprising the CH1 domain, the hinge, the CH2 domain and the CH3 domain as defined in (a), (b), (c) and (d) lacks the GK or K C-terminal. |