| abstract |
MRNA that is complexed with polyethyleneimine (PEI) to provide a combination comprising the mRNA and PEI for use in treating a lung defect by expression of the mRNA in the lung, wherein - the combination comprising the mRNA and PEI goes to be administered to the lung where it enters lung cells; and - the mRNA is to be expressed in lung cells, in which the mRNA codes for cystic fibrosis transmembrane conductance regulator (CFTR), surfactant protein B (SPB), member 3 of the A-binding cassette subfamily A ATP (ABCA3) or alpha-1 antitrypsin (A1AT), surfactant protein C (SPC), erythropoietin, granulocyte-macrophage colony stimulating factor, hepcidin, angiotensin converting enzyme II or antigens of viral or bacterial pathogens, and in the one that said combination is to be administered to the lung by inhalation through a nebulizer, is to be introduced into the airways through a nebulizer, is formulated for inhalation through a nebulizer and / or is formulated for introduction into the airways through a nebulizer. |