| abstract |
A compound that is of the formula: ** (See formula) ** or ** (See formula) ** wherein R1, R2, and R3 are independently selected from the group consisting of methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; isobutyl; sec-butyl; t-butyl; cyclobutyl; -cyclopropyl-methyl; -methyl-cyclopropyl; - C1-C4 haloalkyl, wherein the C1-C4 alkyl portion is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyl, isobutyl, sec-butyl, t-butyl, cyclobutyl , -cyclopropyl-methyl and -methylcyclopropyl; -CN; and -F; and R20 is independently selected from the group consisting of -C1-C20 alkyl, -C1-C20 alkenyl, and -C1-C20 alkynyl; or a stereoisomer, mixture of stereoisomers, solvate or hydrate thereof for use in a method of treating a mitochondrial disorder selected from the group consisting of Leber's hereditary optic neuropathy (LHON); Leigh syndrome; Friedreich's ataxia (FA); Parkinson's disease; amyotrophic lateral sclerosis (ALS); and Huntington's disease; in a subject, wherein the subject is a mammal. |