| abstract |
An effective amount of an isolated antibody or antigen-binding fragment thereof that specifically binds to Semaphorin-4D (SEMA4D) for use in a treatment to inhibit, suppress, reduce, or delay the growth of atherosclerotic plaques in a subject who suffers from atherosclerosis, where the antibody or antigen-binding fragment thereof comprises a variable heavy chain (VH) comprising VH CDRs 1-3 comprising SEQ ID NOs 6, 7 and 8, respectively, and a variable light chain (VL) comprising VL CDRs 1-3 comprising SEQ ID NOs 14, 15 and 16, respectively. |