http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2821790-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fef52dfd583ecdd45acd228f75bd26e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcce39a20bef16c3f04497659caba40f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 2017-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_746de9a281769d38286c2e382c6fff54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22fdac7acf1b4deeb3d02bf5eafae736 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc825570ea28f74af09bed513d3e3730 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8bd1b76ebe85a01178aa841cbe3519a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb9f15f555a6fc2876688c747142c35e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07e970aef66f5b4aadd35ee554398f85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76b47b68a7e0ce5618eab8d7456d2d4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e2cc869e53c8f2e4ff99c7c31f4796a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b6f01d4022af9e9cf11dff99043c5f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9854fdcdce243dc380fd13535bf6d1fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a06be42d00470341777beeeebfe6690 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff26159336a240587eba19897594bd3d |
| publicationDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2821790-T3 |
| titleOfInvention | Integrated stress pathway modulators |
| abstract | A compound of Formula (I): ** (See formula) ** or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or stereoisomer thereof, wherein: D is ** (See formula) ** L1 is CH2O - * or CH2OCH2- *, L2 is selected from CH2O- *, CH2OCH2- *, or -O-, and "- *" indicates the point of attachment to A or Z, respectively; R1 is hydrogen or C1-C6 alkyl; A and W are each independently 5-6 membered phenyl or heteroaryl, wherein each 5-6 membered phenyl or heteroaryl is optionally substituted with 1-5 RY; Z is hydrogen, phenyl, or 5-6 membered heteroaryl, wherein each 5-6 membered phenyl or heteroaryl is optionally substituted with 1-5 RY; each RX is independently selected from the group consisting of C1-C6 alkyl, hydroxy-C1-C6 alkyl, C1-C6 haloalkyl, amino-C1-C6 alkyl, cyano-C1-C6 alkyl, oxo, halo, cyano, -ORA , -NRBRC, -NRBC (O) RD, -C (O) NRBRC, -C (O) RD, -C (O) OH, -C (O) ORD, -SRE, -S (O) RD, and -S (O) 2RD; each RY is independently selected from the group consisting of hydrogen, C1-C6 alkyl, hydroxy-C1-C6 alkyl, halo-C1-C6 alkyl, halo-C1-C6 alkoxy, amino-C1-C6 alkyl, cyano-C1 alkyl -C6, oxo, halo, cyano, -ORA, -NRBRC, -NRBC (O) RD, -C (O) NRBRC, -C (O) RD, -C (O) OH, -C (O) ORD, -S (RF) m, -S (O) RD, -S (O) 2RD, and G1; or 2 RY groups on adjacent atoms, together with the carbon atoms to which they are attached form a 3-7 membered fused cycloalkyl, 3-7 membered fused heterocyclyl, aryl, or optionally substituted 5-6 membered fused heteroaryl 1-5 RX; each G1 is independently 3-7 membered cycloalkyl, 3-7 membered heterocyclyl, aryl, or 5-6 membered heteroaryl, wherein each 3-7 membered cycloalkyl, 3-7 membered heterocyclyl, aryl, or heteroaryl 5-6 membered is optionally substituted with 1-3 RZ; Each RZ is independently selected from the group consisting of C1-C6 alkyl, hydroxy-C1-C6 alkyl, halo C1-C6 alkyl, halo, cyano, -ORA, -NRBRC, -NRBC (O) RD, -C ( O) NRBRC, -C (O) RD, -C (O) OH, -C (O) ORD, and -S (O) 2RD; RA is each independently hydrogen, C1-C6 alkyl, halo-C1-C6 alkyl, -C (O) NRBRC, -C (O) RD, -C (O) OH, or -C (O) ORD ; each of RB and RC is independently hydrogen or C1-C6 alkyl; or RB and RC together with the atom to which they are attached form a 3-7 membered heterocyclyl ring optionally substituted with 1-3 RZ; each RD is independently C1-C6 alkyl or halo-C1-C6 alkyl; each RE is independently hydrogen, C1-C6 alkyl, or halo-C1-C6 alkyl; each RF is independently hydrogen, C1-C6 alkyl, or halo; and m is 1, 3, or 5. |
| priorityDate | 2016-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 2037.