| abstract |
A compound (7S, 13R) -11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo [4,3-f] [1,4,8,10] benzoxatriazazidotridezine -4 (5H) -one, having the formula ** (See formula) ** or a pharmaceutically acceptable salt thereof, for use in treating cancer in a patient, where the cancer is mediated by a protein fusion comprising a fragment of a protein encoded by a ROS1 gene and a fragment of a protein encoded by a gene selected from the group consisting of FIG, TPM3, SDC4, SLC34A2, CD74, EZR and LRIG3. |