| abstract |
A mouse Rag - / -, γc - / -, Flk2 - / - deficient for the recombination activator gene 2 (Rag2) and / or the recombination activator gene 1 (Rag1), interleukin-2 receptor gamma chain (γc ) and fetal liver kinase 2 (Flk2) comprising an alteration in the Rag1 and / or Rag2 gene (s), in the γc gene and the Flk2 gene, (i) with grafted human hematopoietic progenitor cells, and ( ii) to which is administered exogenous human fetal liver kinase 2 ligand (Flk2L). |