abstract |
An antisclerostin antibody or fragment thereof for use in a method for treating a bone-related disorder by increasing bone mineral density in a human, the method comprising administering the antisclerostin antibody or fragment thereof to the human in an amount of 1 mg / kg to 10 mg / kg, where the antisclerostin antibody or fragment thereof cross-blocks the sclerostin binding of the Ab-4 antibody having a heavy chain sequence of SEQ ID NO: 137 and a light chain sequence of SEQ ID NO: 133, or the Ab-13 antibody having a heavy chain sequence of SEQ ID NO: 209 and a light chain sequence of SEQ ID NO: 205. |