http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-281232-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c8d7acffd8a388b8a5ddbb0749ed148 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-74 |
| filingDate | 1962-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1962-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-281232-A1 |
| titleOfInvention | METHOD OF PREPARING A COMPOUND REPRESENTED BY THE FORMULA |
| abstract | The invention comprises: (a) compounds of the general formula: <FORM:0969101/C1/1> (wherein n is 0 or 1, R represents a hydrogen atom or a methyl group, R1 represents an acyl group (including an arylsulphonyl, alkoxycarbonyl and haloalkoxycarbonyl group), A represents a methylene or alkylidene group and Y represents an amino, alkylamino, dialkylamino, acetylamino, hydroxyalkylamino, phenylamino, piperidino, pyrrolidino or morpholino group), and pharmaceutical compositions containing them together with a pharmaceutically acceptable carrier (b) compounds of the general formula: <FORM:0969101/C1/2> (wherein n, R and A are as defined in (a) and B represents an amino, alkylamino or hydroxy group) (c) the preparation of the compounds of (a) by reacting a compound of (b) with an acyl halide (including an aryl monosulphonic acid halide and an alkyl or haloalkyl haloformate), a carboxylic acid anhydride, or formic acid and acetic anhydride, and, when B is OH, treating the product with a halogenating agent and reacting the product with an appropriate primary or secondary amine (d) the preparation of the compounds of (b) by reacting a compound of the general formula: <FORM:0969101/C1/3> with a compound of the general formula: H2NNH-A-CO-B by bringing the reactants together in an acidified medium (e) the preparation of 2-(1-acetyl-2-(5-nitrofurfurylidine)-hydrazino)-diacetamide by treating 2-(5-nitrofurfurylidenehydrazino)- acetamide or its 1-acetyl derivative with acetic anhydride in the presence of concentrated sulphuric acid and (f) the preparation of 2-(1-acetyl -2-(5-nitrofurfurylidene)-hydrazino)-N-hydroxymethylacetamide by reacting 2-(1-acetyl -2-(5-nitrofurfurylidene) - hydrazino) - acetamide with formaldehyde solution in the presence of sodium carbonate. The process of (d) may be modified by replacing the nitrofuran carbonyl compound formulated therein by another carbonyl compound and then hydrolysing the product in the presence of the said nitrofuran carbonyl compound. Sodium hydrazinoacetate is prepared by reacting hydrazine hydrate with chloracetic acid in aqueous caustic soda. Ethyl a -hydrazinopropionate is prepared by refluxing hydrazine hydrate with a -chloropropionic acid in ethanol and then saturating the solution with dry hydrogen chloride gas. The pharmaceutical compositions, which have antimicrobial (including anthelmintic and antiprotoyoal) activity, may be in the form of tablets, suspensions, elixirs, capsules or troches, or foodstuffs or drinking water for animals. |
| priorityDate | 1961-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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