| abstract |
A compound of Formula (II): ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: - R1 is H; - R2 is H, aralkyl or heterocyclyl; - m and n are independently an integer from 0 to 1; - x is an integer from 0 to 4; - y is an integer from 0 to 3; - A is a cycloalkyl, heterocycloalkyl, aromatic or heteroaromatic ring containing the ring moieties Q1, Q2, Q3 and Q4, which are taken together with the carbons in the a and a 'positions to form ring A; - B is a cycloalkyl, heterocycloalkyl, aromatic or heteroaromatic ring containing the ring moieties Q5, Q6, Q7 and Q8, which are taken together with the carbons in the a and a 'positions to form ring B; - Q1, Q2, Q3, Q4, Q5, Q6, Q7 and Q8 are independently selected from the group consisting of C, CH2, CH, N, NR10, O and S, provided that (1) rings A and B form in naphthalene set, x is an integer from 1 to 3 or y is an integer 2 or 3 or R8 is other than Cl, or (2) at least one of Q1, Q2, Q3, Q4, Q5, Q6, Q7 and Q8 let N, NR10, O or S; - each R8 and R9 is independently selected from halo, alkylsulfonyl, N-hydroxylsulfonamidyl, perhaloalkyl, nitro, cyano, alkoxy, perhaloalkoxy, alkyl, substituted aryloxy, alkylsulfanyl, alkylsulfinyl, heterocycloalkyl, substituted heterocycloalkyl, NH2, OH, C (substituted heterocycloalkyl, NH2), OH, C , C (O) Oalkyl, NHC (O) alkylC (O) OH, C (O) NH2, NHC (O) alkylC (O) alkyl, NHC (O) alkenylC (O) OH, NHC (O) NH2, OalkylC (O) Oalkyl, NHC (O) alkyl, C (= NOH) NH2, cycloalkoxy, cycloalkylsulfanyl, arylsulfanyl, and arylsulfinyl; - R10 is H, alkyl, acyl or sulfonyl; subject to the condition that the compound of Formula (II) or the pharmaceutically acceptable salt thereof is not one of the following compounds X1, X2, X3 and X4: ** (See formula) ** |