http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2807849-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 |
| filingDate | 2016-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caa6d472af07d48850f89e47f7aa8e5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dd8cfa215c4f6cb174944805723fc5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9536ccb3abe49eb4fcec39ace6c068ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_239ef5f467a8b1e7f3280cf9013380e0 |
| publicationDate | 2021-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2807849-T3 |
| titleOfInvention | Oxadiazole derivatives microbicides |
| abstract | A compound of formula (I): ** (See formula) ** where n is 1 or 2 A1 represents N or CR1, where R1 is hydrogen, halogen, methyl, ethyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy or difluoromethoxy; A2 represents N or CR2, where R2 is hydrogen, halogen, methyl, ethyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy or difluoromethoxy; A3 represents N or CR3, where R3 is hydrogen or halogen; A4 represents N or CR4, where R4 is hydrogen or halogen; and where 0, 1 or 2 of A1, A2, A3 and A4 are N; R5 and R6 are independently selected from hydrogen, C1-4 alkyl, halogen, cyano, trifluoromethyl, and difluoromethyl, or R5 and R6, together with the carbon atom they share, form a cyclopropyl; R7 is hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 hydroxyalkyl, C1-2alkoxyC1-4alkyl, C1-2alkoxyC1-4alkyl, C3-6 alkenyl, C3-4 alkynyl, C3-6 alkenyloxy, C3-6 alkynyloxy, C3-6 haloalkenyl, C3-6 haloalkenyloxy, C1-4 alkylcarbonyloxy, C1-4 haloalkylcarbonyloxy, C1-4 alkoxycarbonyloxy, C1-4 alkylcarbonyloxy C1-4alkyl, C1-4 haloalkylcarbonyloxy or C1-4 alkoxycarbonyloxyC 1-4alkyl; or R7 is C3-6 cycloalkyl, C3-6 cycloalkyl, C1-2alkyl, C3-6 cycloalkyl, C1-2 alkoxy, phenyl, phenylC1-2 alkyl, phenylalkoxy, C1-2, heteroaryl, heteroarylalkyl, C1-2, heteroarylalkoxy, C1-2, heterocyclyl, C1-2 heterocyclylalkyl, C1-2 heterocyclylalkoxy, C3-6 cycloalkylcarbonyloxy, heterocyclylcarbonyloxy, phenylcarbonyloxy, C3-6 cycloalkylcarbonyloxyC1-4alkyl, heterocyclylcarbonyloxyalkyl or phenylcarbonyloxyalkyl, or phenylcarbonyloxyalkyl, where the C1-4 aromatic or phenylcarbonyloxyalkyl moiety is on a C1-4 aromatic ring or phenylcarbonyloxyalkyl 6-membered comprising 1, 2, 3, or 4 heteroatoms individually selected from N, O, and S, the heterocyclyl moiety is a 4- to 6-membered non-aromatic ring comprising 1 or 2 heteroatoms individually selected from N, O, and S, and wherein any of said cycloalkyl, phenyl, heteroaryl, and heterocyclyl moieties are optionally substituted with 1 or 2 substituents selected from cyano, fluorine, chlorine, bromine, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, or difluoro romethoxy; R8 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 cyanoalkyl, C1-6 haloalkyl, C2-6 haloalkenyl, C1-6 hydroxyalkyl, C1-4 alkoxyC1-6alkyl, C1-6 haloalkoxy 4C 1-6 alkyl, C1-4 alkoxyC 1-4 alkoxyC 1-6alkyl, C 2-4C 1-6 alkynyloxy, aminoC 1-6 alkyl, N -C 1-4 alkylaminoC 1-6 alkyl, N, N-dialkylaminoC 1-4C 1-6alkyl , C1-6 alkylcarbonylC1-6alkyl, C1-6alkylcarbonylC2-6alkenyl, C1-6alkoxycarbonylC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl, NalkylaminocarbonylC1-4C1-6alkyl, N, N-dialkylaminocarbonylC1-4alkyl -6, C1-6 alkylsulfanylC 1-6alkyl, C1-6 alkylsulfonylC 1-6 alkyl, C1-6 alkylsulfonylaminoC 1-6alkyl, C1-6 alkylsulfonylaminoC2-6 alkynyl, C1-6 alkynyloxycarbonylaminoC2-6alkyl, C1-4 alkylcarbonylaminoC 1-4alkyl 6 or C1-4 alkoxycarbonylamino C1-6alkyl; or R8 is C3-8 cycloalkyl, C3-8 cycloalkyl C1-6alkyl, where the cycloalkyl moiety is optionally partially unsaturated, phenyl, phenylC1-6alkyl, phenylalkenylC2-6, naphthyl, naphthylC1-6alkyl, heteroaryl, heteroarylC1-6kyl , where the heteroaryl moiety is a 5- or 6-membered monocyclic, aromatic ring comprising 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, heterodyryl, heterodyrylalkyl C1-6 where the heterodyryl moiety is an aromatic system, bicyclic, 9 to 10 membered comprising 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, heterocyclyl, heterocyclylalkyl C1-6 where the heterocyclyl moiety is a 4 to 6 membered non-aromatic ring comprising 1, 2 or 3 heteroatoms individually selected from N, O and S or C3-6 cycloalkylcarbonylaminoC 1-6alkyl, where for R8, any cycloalkyl, phenyl, naphthyl, heteroaryl, heterodyryl or heterocyclyl moiety is optionally substituted with 1, 2 or 3 substituents, which can be the same or different, selected from R9; or, additionally, when R8 is cyclopropyl, the cyclopropyl moiety is substituted with 4 substituents, which may be the same or different, selected from R9, provided that at least 2 R9 substituents are the same; where R9 is cyano, halogen, hydroxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C2-4 haloalkenyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-4 alkynyloxy, N -C 1-4 alkylamino, N, N-C1-4 dialkylamino, C1-4 alkylcarbonyl, cycloalkylcarbonyl or C3-6, C1-4 alkoxycarbonyl, carbonylamino, N-C1-4 alkylaminocarbonyl, N, N-dialkylaminocarbonyl C1-4 or alkoxycarbonylamino C1-4, and where when R8 is C3-8 cycloalkyl C1-6alkyl, heterocyclyl, heterocyclylC1-6 alkyl or substituted C3-8 cycloalkyl, R9 may also represent oxo in the C3-8 cycloalkyl or heterocyclyl moiety; or where for R8, any cycloalkyl, phenyl, naphthyl, heteroaryl, heterodyaryl or heterocyclyl moiety is optionally substituted with 1 substituent selected from R10 and further optionally substituted with 1 or 2 substituents selected from R9; where R10 is C3-8 cycloalkyl, C3-8 cycloalkylC1-2alkyl, phenyl, phenylC1-2alkyl, heteroaryl, heteroarylC1-2alkyl where the heteroaryl moiety is a 5- or 6-membered monocyclic, aromatic ring comprising 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, heterocyclyl or heterocyclylalkyl C1-6 where the heterocyclyl moiety is a 4- to 6-membered non-aromatic ring comprising 1, 2 or 3 heteroatoms individually selected from N, O and S, and where any of said cycloalkyl, phenyl, heteroaryl and heterocyclyl moieties are optionally substituted with 1, 2 or 3 substituents, which may be the same or different, selected from R11; where R11 is hydrogen, cyano, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxy, and ethoxy; or R8 represents -OR12, where R12 is hydrogen, C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, C1-6 cyanoalkyl, C1-6 haloalkyl, C3-6 haloalkenyl, C1-6 hydroxyalkyl, C1-4alkyl C1-6 haloalkoxyC 1-4alkyl, C1-4 alkoxyC 1-4alkylC 1-6, aminoC 1-6 alkyl, N-C 1-4 alkylaminoC 1-6 alkyl, N, N-dialkylaminoC 1-4C 1-6alkyl, C1-6 alkylcarbonylC 1-6alkyl, C1-6 alkylcarbonylC2-6alkenyl, C1-6 alkoxycarbonylC 1-6alkyl, C1-6 alkylcarbonyloxyC 1-6alkyl, N-alkylaminocarbonylC 1-4alkyl, N, N-dialkylaminocarbonylC 1-4alkyl C 1-6, C 1-4 alkylsulfanylC 1-6 alkyl, C 1-6 alkylsulfonylC 1-6 alkyl or C 1-6 alkylsulfonylaminoC 1-6 alkyl; or R12 is C3-8 cycloalkyl, C3-8 cycloalkyl C1-6alkyl, where the cycloalkyl moiety is phenyl, phenylC1-6 alkyl, heteroaryl, optionally partially unsaturated heteroaryl C1-6 alkyl, where the heteroaryl moiety is an aromatic, monocyclic ring of 5 or 6-membered comprising 1, 2, 3, or 4 heteroatoms individually selected from N, O, and S, heterocyclyl or heterocyclylC 1-6 alkyl, where the heterocyclyl moiety is a 4- to 6-membered non-aromatic ring comprising 1, 2, or 3 heteroatoms individually selected from N, O and S, where for R12, any cycloalkyl, phenyl, heteroaryl or heterocyclyl moiety is optionally substituted with 1, 2 or 3 substituents, which may be the same or different, selected from R13; where R13 is cyano, halogen, hydroxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C2-4 haloalkenyl, C1-4 alkoxy, C1-4 haloalkoxy, C3-4 alkenyloxy, alkynyloxy C3-4, N-C1-4 alkylamino, N, N-dialkylamino C1-4, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, carbonylamino, N-C1-4 alkylaminocarbonyl, N, N-dialkylaminocarbonyl C1-4 or C1-4 alkoxycarbonylamino -4; and where when R12 is C3-8 cycloalkyl, C3-8 cycloalkyl C1-6alkyl, heterocyclyl or substituted C1-6 heterocyclylalkyl, R13 may also represent oxo in the C3-8 cycloalkyl or heterocyclyl moiety; or R8 represents -NR14R15, where R14 is hydrogen, cyano, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 alkenyloxy, C3-6 alkynyloxy, C1-6 cyanoalkyl, C1- haloalkyl -6, C1-6 haloalkenyl, C1-6 hydroxyalkyl, C1-4 alkoxyC 1-6alkyl, C1-4 haloalkoxyC 1-6alkyl, C1-4 alkoxyC 1-4alkylC 1-6, aminoC 1-6 alkyl, N-C1- alkylamino 4C 1-6alkyl, N, NdialkylaminoC 1-4C 1-6alkyl, C 1-6 alkylcarbonylC 1-6alkyl, C 1-6 alkylcarbonylC 2-6alkenyl, C 1-6 alkoxycarbonylC 1-6 alkyl, C 1-6 alkylcarbonyloxyC 1-6alkyl, N-alkylaminocarbonyl C 1-4C 1-6 alkyl, N, N-dialkylaminocarbonylC 1-4C 1-6alkyl, C 1-4 alkylsulfanylC 1-6alkyl, C 1-6 alkylsulfonylC 1-6 alkyl or C 1-6 alkylsulfonylaminoC 1-6alkyl; or R14 is C3-8 cycloalkyl, C3-8 cycloalkyl, C1-6 alkyl, C3-8 cycloalkyl, C1-6 alkoxy, C3-6 cycloalkyloxy, where the cycloalkyl moiety is phenyl, phenylC1-6 alkyl, phenylC1-6 alkoxy, heteroaryl, heteroaryl C1-6 alkyl -6, optionally partially unsaturated C1-6 heteroarylalkoxy, where the heteroaryl moiety is a 5- or 6-membered monocyclic, aromatic ring comprising 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, heterocyclyl, C1- heterocyclylalkyl 6 or C 1-6 heterocyclylalkoxy where the heterocyclyl moiety is a 4- to 6-membered non-aromatic ring comprising 1, 2 or 3 heteroatoms individually selected from N, O and S, where for R14, any cycloalkyl, phenyl, heteroaryl, heterocyclyl moiety is optionally substituted with 1, 2 or 3 substituents, which may be the same or different, selected from R17; where R16 is cyano, halogen, hydroxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C2-4 haloalkenyl, C1-4 alkoxy, C1-2 alkoxyC1-2alkyl, C1-4 haloalkoxy 4, C3-4 alkenyloxy, C3-4 alkynyloxy, N-C1-4 alkylamino, N, N-dialkylamino C1-4, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, carbonylamino, N-C1-4 alkylaminocarbonyl, N, N -C 1-4 dialkylaminocarbonyl and C1-4 alkoxycarbonylamino; and where when R14 is C3-8 cycloalkyl, C3-8 cycloalkyl C1-6alkyl, C3-8 cycloalkylC1-5alkoxy, heterocyclyl, heterocyclylalkyl, C1-6 substituted or heterocyclylalkoxy, R16 may also represent oxo in the C3 cycloalkyl moiety. - 8 or heterocyclyl; R15 is hydrogen, C1-4 alkyl, C3-4 alkynyl, C1-4 alkoxyC1-4alkyl, cyanoC1-4alkyl, C3-6 cycloalkyl, C3-6 cycloalkylC1-2alkyl; or R14 and R15, together with the nitrogen atom to which they are attached, form a 4-, 5- or 6-membered ring optionally containing an additional heteroatom or group selected from O, S, S (O) 2, oxo (= O ) and NR17; where R17 is hydrogen, methyl, methoxy, formyl, or acyl; or one of its salts or N-oxides. |
| priorityDate | 2015-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1527.