http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2806631-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b2a58b1af4d43f099830cb7a6a2cbd6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 |
| filingDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98b1444d92b6e22fec5119cec521404d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7064bdf018799d1c6ac61fbb37677b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f1c443668d5451e832c64c45fb3f1d5 |
| publicationDate | 2021-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2806631-T3 |
| titleOfInvention | Preparation of sufentanil citrate and sufentanil base |
| abstract | A process for forming sufentanil citrate from sufentanil base, the process comprising: (a) contacting the sufentanil base with a non-aqueous polar solvent to form a mixture, wherein the volume-to-mass ratio (ml: g ) of the non-aqueous polar solvent to the sufentanil base is 2: 1 to 12: 1 and the contacting occurs at a temperature of 70 ° C to 90 ° C; (b) contacting the mixture with citric acid to form a sufentanil citrate mixture, wherein contacting occurs at a temperature of 70 ° C to 90 ° C and the sufentanil citrate mixture is free of a oil phase; (c) cooling the sufentanil citrate mixture to a temperature of 50 ° C to 60 ° C to form solid sufentanil citrate; and (d) recovering the sufentanil citrate at a temperature of 50 ° C to 60 ° C. |
| priorityDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.