http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2806460-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_88bdeccb9b4def5555fe68a9f0ad2589 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-60 |
| filingDate | 2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_091821bf2a3def1f83cf66d0fdd08bff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28ebdbbff4bac33d4a4a84d9acd1bcad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_794579e079a94c4f16dabef4c3a3d4e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea1c2a59a0117dd5d7bf31530bfc1768 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_915b4495b876f67edbfdfd47a4bb2efa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f526386358ebc4ceadb029ba41fe231 |
| publicationDate | 2021-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2806460-T3 |
| titleOfInvention | Process for the preparation of 4-aminoindan derivatives and related aminoindan amides |
| abstract | A process for the preparation of 4-aminoindane derivatives of Formula (I), salts and enantiomers thereof ** (See formula) ** comprising the following steps: a) hydrogenate a 1,2-dihydroquinoline of Formula (IV ) ** (See formula) ** to give a corresponding tetrahydroquinoline of Formula (V) ** (See formula) ** b) acylate the tetrahydroquinoline of Formula (V) with a carboxylic acid derivative of Formula RC (O) LG to obtain a corresponding acyl derivative compound of Formula (VI) ** (See formula) ** c) rearrange the acyl derivative compound of Formula (VI) under acidic conditions to give an acyl indane compound of Formula ( VII) ** (See formula) ** d) hydrolyze the acyl group of the acyl indane compound of Formula (VII) to obtain the 4-aminoindan compound of Formula (I), where, in said Formulas: - n is an integer selected within the range 0 to 3; - R is selected from a C1-C6 alkyl group or a C6-C10 aryl group, these groups being optionally substituted with one or more of: C1-C6 alkyl groups, halogen atoms; - LG is a leaving group selected from: (i) a hydroxy group; (ii) a halogen atom; (iii) a C1-C6 alkylsulfonyloxy group; (iv) a C6-C10 arylsulfonyloxy group, (v) a RaCOO group, where Ra is a C1-C6 alkyl group, the groups (iii) - (v) being optionally substituted with one or more halogen atoms. |
| priorityDate | 2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 121.