abstract |
Compound of Formula IIb 'or Formula IId': ** (See formula) ** or a stereoisomer, tautomer, pharmaceutically acceptable salt or hydrate thereof, wherein: rings A and B may be optionally substituted with groups independently selected from deuterium, -NH2, amino, heterocycle (C4-C6), carbocycle (C4-C6), halogen, -CN, -OH, -CF3, alkyl (C1-C6), thioalkyl (C1-C6), alkenyl (C1- C6), and (C1-C6) alkoxy; X is selected from -NH-, -CH2-, -CH2CH2-, -CH2CH2CH2-, -CH2CH2O-, -CH2CH2NH-, -CH2CH2S-, -C (O) -, - C (O) CH2-, -C ( O) CH2CH2-, -CH2C (O) -, -CH2CH2C (O) -, -C (O) NH-, -C (O) O-, -C (O) S-, -C (O) NHCH2- , -C (O) OCH2-, - C (O) SCH2-, -CH (OH) - and -CH (CH3) -, where one or more hydrogens can be independently substituted with deuterium, hydroxy, methyl, halogen, - CF3, ketone, and where S can be oxidized to sulfoxide or sulfone; R4 is selected from 3-7 membered carbocycles and heterocycles, optionally substituted with groups independently selected from deuterium, (C1-C4) alkyl, (C1-C4) alkoxy, amino, halogen, amide, -CF3, CN, -N3, (C1-C4) ketone, -S (O) (C1-C4) alkyl, -SO2 (C1-C4) alkyl, (C1-C4) thioalkyl, carboxyl, and / or ester, each of which may optionally be substituted with hydrogen, F, Cl, Br, -OH, -NH2, -NHMe, -OMe, -SMe, oxo, and / or thiooxo; and D1 is selected from the following 5-membered monocyclic heterocycles: ** (See formula) ** which are optionally substituted with deuterium, (C1-C4) alkyl, (C1-C4) alkoxy, amino, halogen, amide, -CF3 , CN, -N3, (C1-C4) ketone, -S (O) (C1-C4) alkyl, -SO2 (C1-C4) alkyl, (C1-C4) thioalkyl, -COOH, and / or ester, each one of which may be optionally substituted with hydrogen, F, Cl, Br, -OH, -NH2, -NHMe, -OMe, -SMe, oxo, and / or thiooxo; wherein each amino, when present, has the form -NRdRe or -N (Rd) Re-, where Rd and Re are independently selected from alkyl, alkenyl, alkynyl, aryl, arylalkyl, carbamate, cycloalkyl, haloalkyl, heteroaryl, heterocycle and hydrogen, and wherein Rd and Re can join to form a 3- to 12-membered ring, and wherein each amino is optionally substituted with at least one group selected from alkoxy, aryloxy, alkyl, alkenyl, alkynyl, amide , amino, aryl, arylalkyl, carbamate, carbonyl, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, phosphate, sulfide, sulfinyl, sulfonyl, sulfonic acid, sulfonamide, thioketone, ureido and N. |