http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2806123-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-12 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C25-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C17-12 |
filingDate | 2015-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d8156e4e0f9a3e0e7fb7d1cf79d92ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4aabe3b40f055d8f1e73a977f612af9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98800275feb456d575a24edd87ce5dd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bc9b28d84580db4659af39e6b219986 |
publicationDate | 2021-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2806123-T3 |
titleOfInvention | Procedure for the preparation of halo-substituted benzenes |
abstract | A process for the preparation of a compound of formula I ** (See formula) **, wherein R1 is halogen and R2 is hydrogen or R1 is chlorine and R2 is halogen; comprising a) for the preparation of a compound of formula I, wherein R1 is halogen and R2 is hydrogen, reacting the compound of formula II ** (See formula) ** in an aprotic organic solvent in the presence of a co- polar aprotic solvent selected from the group consisting of the compounds of formula VI ** (See formula) **, wherein R8 and R9 are, independently of each other, C1-C6 alkyl, C4-C7 cycloalkyl or C1-C6 alkoxylalkyl and the two R10 together represent a -CH2-CH2- or -CH2-CH2-CH2- chain; with a magnesium amide base which is a compound of formula IV ** (See formula) ** complexed with lithium chloride; wherein R3 and R4 are, independently of each other, C1-C6 alkyl, C4-C7 cycloalkyl or C1-C6 alkoxyalkyl; and X is halogen, followed by a halogenating agent, to give the compound of formula I ** (See formula) ** wherein R1 is halogen and R2 is hydrogen; and b) for the preparation of a compound of formula I, where R1 is chlorine and R2 is halogen, reacting the compound of formula I, where R1 is chlorine and R2 is hydrogen, in an aprotic organic solvent in the presence of a co -polar aprotic solvent selected from the group consisting of the compounds of formula VI ** (See formula) ** wherein R8 and R9 are, independently from each other, C1-C6 alkyl, C4-C7 cycloalkyl or C1-C6 alkoxyalkyl and the two R10 together represent a -CH2-CH2- or -CH2-CH2-CH2- chain; with a magnesium amide base which is a compound of formula IV ** (See formula) ** complexed with lithium chloride; wherein R3 and R4 are, independently of each other, C1-C6 alkyl, C4-C7 cycloalkyl or C1-C6 alkoxyalkyl; and X is halogen, followed by a halogenating agent, to give a compound of formula I, wherein R1 is chlorine and R2 is halogen. |
priorityDate | 2014-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.