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publicationDate 2021-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2802299-T3
titleOfInvention Missed dose dosing regimen for long-acting injectable paliperidone esters
abstract An injectable paliperidone palmitate depot for use in treating a patient in need of selected psychiatric treatment of psychosis, schizophrenia, or bipolar disorder who has been treated with a quarterly injectable paliperidone palmitate depot, where said patient has forgotten for a period of nine months or more the next scheduled maintenance dose of the quarterly injectable paliperidone palmitate depot, for a dosage regimen comprising: (1) administering intramuscularly into the deltoid muscle of said patient a first rebooting loading dose 150 mg eq. a depot of injectable paliperidone palmitate monthly; (2) administer intramuscularly into the deltoid muscle of said patient a second reboot dose of 100 mg eq. of the depot of injectable paliperidone palmitate monthly between about the 4th day and about the 12th day after the administration of said first reboot loading dose; (3) administer intramuscularly into the deltoid or gluteal muscle of said patient a first restart maintenance dose of 50 mg eq. to about 150 mg eq. from the monthly injectable paliperidone palmitate depot on about the 37th day to about the 37th day after the second reboot loading dose is administered; (4) administering intramuscularly into the deltoid or gluteal muscle of said patient a second restart maintenance dose of approximately 50 mg eq. to about 150 mg eq. of the depot of injectable paliperidone palmitate monthly between about the 23rd day and about the 37th day after the administration of the first additional maintenance dose; (5) administer intramuscularly into the deltoid or gluteal muscle of said patient a third maintenance restart dose of approximately 50 mg eq. to about 150 mg eq. of the depot of injectable paliperidone palmitate monthly between about the 23rd day and about the 37th day after the administration of the second maintenance dose; and (6) intramuscularly administering approximately 175 mg eq into the deltoid or gluteal muscle of said patient. to about 525 mg eq. of the quarterly formulation of paliperidone palmitate between about the 23rd day and about the 37th day after the administration of the third monthly maintenance dose of injectable paliperidone palmitate.
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