http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2802274-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a708524c0adee3eb5b130dac053f9c3d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2440-38 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-99003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-99001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-14 |
| filingDate | 2014-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff9013ee682986dd244aab2c996835ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3df801bb1671db8155990d9e81ef81fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e302138aa12b7dcf9ed5a8dcff9081e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b15e776b81e201c9467f209f342a9bfa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bd57a84262b7212b6334d6066ca3298 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_149feba0afabd3575db75cba75ca2658 |
| publicationDate | 2021-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2802274-T3 |
| titleOfInvention | Sialylated glycoproteins |
| abstract | A process for producing a glycoprotein preparation comprising Fc regions comprising branched glycans comprising an α1.3 arm and an α1.6 arm, wherein the preparation is an IVIG preparation comprising a target level of disialylated branched glycans having a sialic acid in an α1,3 arm and in an α1,6 arm, where the target level of disialylated branched glycans having a sialic acid in an α1,3 arm and in an α1,6 arm is at least 60 % of sialylated branched glycans, the method comprising: providing an IVIG preparation, wherein the IVIG preparation comprises a plurality of glycoproteins comprising Fc regions comprising branched glycans comprising an α1,3 arm and an α1,6 arm ; and contacting the IVIG preparation with an ST6 sialyltransferase and a sialic acid donor under sufficient reaction conditions for the ST6 sialyltransferase to add substantially a sialic acid to an α1,3 arm and to an α1,6 arm of a branched glycan, and are not sufficient for ST6 sialyltransferase to substantially remove a sialic acid from an α1,3 arm of a branched glycan, where ST6 sialyltransferase is a polypeptide involved in the transfer of a sialic acid to a terminal galactose of a glycan a via an α2,6 bond, and wherein the reaction conditions comprise supplementing the sialic acid donor at least once during the reaction; thus producing an IVIG preparation that has the target level of disialylated branched glycans having a sialic acid in the α1,3 arm and in the α1,6 arm. |
| priorityDate | 2013-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 509.