http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2794581-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80c161e2f67152e2918a185e322177c2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0478 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01G15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C251-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C01G15-00 |
| filingDate | 2016-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31ad8e8030b1251e0230267b96dd64ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8b0c2683adb1608439b24b552db00e9 |
| publicationDate | 2020-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2794581-T3 |
| titleOfInvention | Procedures and kits for preparing radionuclide complexes |
| abstract | A process for preparing a complex comprising a gallium radioisotope for use in radiotherapy or in a medical imaging procedure, said process comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer, and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein The composition further comprises a chelator that is capable of chelating radioactive gallium within said pH range and at a moderate temperature, said chelator being optionally linked to a target biological agent, wherein said chelator is selected from deferoxamine B (DFO), acid bis (2-hydroxybenzyl) ethylenediamine diacetic acid (HBED), 1,4,7-triacyclononane macrocycle substituted with phosph groups ionic in amines (NOTP), or a compound of formula (I) ** (See formula) ** or a salt thereof; wherein one of X and Y is C = 0 and the other is NR; wherein each m and p are independently selected from 0 to 6; wherein R1 is a chelating group capable of chelating a radionuclide and is selected from: ** (See formula) ** wherein R, R2, R3 and R4 are independently hydrogen or an optionally substituted C1-7 alkyl group; and where Z is hydrogen or a group of the formula -B'-H, -B'-A, or a group -B'-A * -T, where T is a target group capable of binding to a target of interest in a subject; A is a reactive group that allows coupling to group T, A * is a reactive group A that has reacted; B 'is a linking group to link the chelating group with a reactive group A, and is represented by the formula: ** (See formula) ** in which each Q is independently selected from a group consisting of -NR5- , -C (O) NR5-, -C (O) O, -NR5C (O) NR5-, -NR5C (S) NR5- and -0-, each R5 is independently hydrogen or an optionally substituted C1-7 alkyl group , each q and s are independently selected from 0 to 6 and each r is independently selected from 1 to 6. |
| priorityDate | 2015-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 212.